Author

L. Viney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Assay:CITE-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Choudhry· 3 shared T. Henley· 3 shared B. R. Webber· 2 shared B. S. Moriarity· 2 shared M. J. Johnson· 2 shared C. A. Klebanoff· 1 shared C. M. Kariya· 1 shared C. Yan· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCancer Biology

M. Choudhry

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Genetic editing of CISH enhances T cell effector programs independently of immune checkpoint cell surface ligand expression

E. Arthofer, K. Chakraborty, L. Viney, M. J. Johnson, B. R. Webber, B. S. Moriarity, E. Lou, M. Choudhry, C. A. Klebanoff, T. Henley

This study shows that genetic editing of CISH enhances T cell anti-tumor activity independently of PD-L1 expression, outperforming PD-1 and TIGIT disruption in certain contexts.

bioRxiv · Aug 17, 2021 · PreprintCancer Biology

AAV Capsid Chimeras with Enhanced Infectivity reveal a core element in the AAV Genome critical for both Cell Transduction and Capsid Assembly

L. Viney, T. Bürckstümmer, M. Mietzsch, M. Choudhry, T. Henley, M. Agbandje-McKenna

This paper develops an AAV chimera, AAV-XV, with enhanced T cell transduction efficiency at lower doses and identifies a critical genomic region for both capsid assembly and transduction.

bioRxiv · Oct 13, 2020Cell Biology

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

D. C. Palmer, B. R. Webber, Y. Patel, M. J. Johnson, C. M. Kariya, W. S. Lahr, M. R. Parkhurst, J. J. Gartner, T. D. Prickett, F. J. Lowery, R. J. Kishton, D. Gurusamy, Z. Franco, S. K. Vodnala, M. D. Diers, , N. P. Restifo

This study shows that CISH knockout in TIL enhances neoantigen reactivity and synergizes with PD1 blockade to improve tumor regression.

bioRxiv · Sep 24, 2020Immunology