M. Agbandje-McKenna

This paper develops an AAV chimera, AAV-XV, with enhanced T cell transduction efficiency at lower doses and identifies a critical genomic region for both capsid assembly and transduction.

This study reveals that AAV capsid assembly is highly stochastic and heterogeneous, with each capsid having a unique composition.

This paper demonstrates that Orbitrap-based single particle charge detection mass spectrometry can resolve high-mass heterogeneous biomolecular assemblies by accurately predicting charge states and masses.

This study investigates chapparvoviruses, revealing they are an ancient lineage infecting both vertebrates and invertebrates with distinct genomic and structural features.

The paper improves cryo-EM resolution by correcting Ewald sphere curvature, achieving 1.86 Å resolution for an AAV2 variant.

The paper identifies and analyzes endogenous parvovirus-like elements in vertebrate genomes, revealing evolutionary relationships and genomic features of parvoviruses.