Author

L.-A. Fournier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

J. P. Wells· 3 shared P. C. Stirling· 3 shared D. G. Huntsman· 2 shared E. Su· 2 shared E. Y.-C. Chang· 2 shared M. Hirst· 2 shared T. Smith· 2 shared Y. D. Zhu· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCell Biology

J. P. Wells

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Author profile →

4 papers

Recent·Most cited

Genome-wide CRISPR screen identifies KEAP1 perturbation as a vulnerability of ARID1A-deficient cells

L.-A. Fournier, F. Kalantari, J. P. Wells, J. S. Lee, G. Trigo-Gonzalez, M. M. Moksa, T. Smith, J. White, A. Shanks, L. Wang, E. Su, Y. Wang, D. G. Huntsman, M. Hirst, P. C. Stirling

The paper identifies KEAP1 as a genetic dependency in ARID1A-deficient clear cell ovarian carcinoma cells through a genome-wide CRISPR screen, showing KEAP1 perturbation leads to growth inhibition.

bioRxiv · Nov 14, 2023Cancer Biology

Global prediction of candidate R-loop binding and R-loop regulatory proteins

L.-A. Fournier, A. Kumar, T. Smith, E. Su, M. Moksa, M. Hirst, P. C. Stirling

The paper develops a random forest classifier to predict R-loop binding proteins using proteomic features and amino acid composition, and validates new R-loop modulating proteins through CRISPR screening.

bioRxiv · Aug 9, 2021 · PreprintCell Biology

ARID1A regulates R-loop associated DNA replication stress

P. Stirling, S. Tsai, E. Y.-C. Chang, L.-A. Fournier, J. P. Wells, S. W. Minaker, Y. D. Zhu, A. Y.-H. Wang, Y. Wang, D. G. Huntsman

This study shows that ARID1A loss causes DNA replication stress linked to R-loops and transcription-replication conflicts in human cells.

bioRxiv · Nov 16, 2020Cell Biology

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts

E. Y.-C. Chang, J. P. Wells, S.-H. Tsai, Y. Coulombe, Y. A. Chan, Y. D. Zhu, L.-A. Fournier, P. Hieter, J.-Y. Masson, P. C. Stirling

The paper identifies MRE11-RAD50-NBS1's role in suppressing R-loops at transcription-replication conflicts through non-nucleolytic functions and Fanconi Anemia pathway interactions.

bioRxiv · Nov 17, 2018Cell Biology