J. White

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance

This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.

Warm temperature inhibits cytoplasmic incompatibility induced by endosymbiotic Rickettsiella in a spider host

This study investigates how temperature affects cytoplasmic incompatibility (CI) in Rickettsiella-infected spiders, finding that warm temperatures reduce CI induction but not rescue.

T-cells specific for KSHV and HIV migrate to Kaposi sarcoma tumors and persist over time

The paper identifies KSHV- and HIV-specific T-cells in KS tumors and shows they persist over time and coexist with immunosuppressive macrophages.

Genome-wide CRISPR screen identifies KEAP1 perturbation as a vulnerability of ARID1A-deficient cells

The paper identifies KEAP1 as a genetic dependency in ARID1A-deficient clear cell ovarian carcinoma cells through a genome-wide CRISPR screen, showing KEAP1 perturbation leads to growth inhibition.

The grass that built the Central Highland of Madagascar: environmental niches and morphological diversity of Loudetia simplex

This study examines the environmental and morphological variation of Loudetia simplex in Madagascar and Africa, finding that Malagasy populations represent a single species with distribution patterns linked to environmental factors.

Endosymbiont diversity across native and invasive brown widow spider populations

The paper examines endosymbiont diversity in native and invasive brown widow spiders, finding widespread Rhabdochlamydia and geographic variation in Wolbachia prevalence.

Development of a Plasmodium vivax biobank for functional ex vivo assays

This study develops an optimized cryopreservation method for Plasmodium vivax isolates and validates its effectiveness for long-term storage and functional assays.

RAD18 opposes transcription-associated genome instability through FANCD2 recruitment

This study shows RAD18 recruits FANCD2 to suppress R-loops and transcription-replication conflicts, reducing genome instability during DNA replication stress.

Pseudomonas aeruginosa utilises host-derived polyamines to facilitate antimicrobial tolerance

This study shows that Pseudomonas aeruginosa uses host-derived polyamines, like spermidine, to enhance antimicrobial tolerance during infection, despite reduced susceptibility in vitro.

Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline

This study examines the impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline, finding progressive telomere erosion and infertility without bone marrow failure.

Nonsterile immunity to cryptosporidiosis in infants is associated with mucosal IgA against the sporozoite and protection from malnutrition

This study links nonsterile immunity to cryptosporidiosis in infants with mucosal IgA against Cp23 and reduced growth faltering.

Phosphorylation of the selective autophagy receptor TAX1BP1 by canonical and noncanonical IκB kinases promotes its lysosomal localization and clearance of MAVS aggregates

This study shows that phosphorylation of TAX1BP1 by IκB kinases promotes its lysosomal degradation and enhances its ability to clear MAVS aggregates.

Insights into glycan import by a prominent gut symbiont

This study characterizes the SusCD protein complex in Bacteroides thetaiotaomicron to elucidate its role in glycan uptake, revealing structural and functional insights into ligand binding and transport dynamics.

Democratizing water monitoring: Implementation of a community-based qPCR monitoring program for recreational water hazards.

This study develops and evaluates a community-based qPCR program for assessing bacterial and parasitic hazards in recreational water, finding high reproducibility between non-expert and expert results.

Dynamic oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis

This study identifies RagAB as the oligopeptide transporter in P. gingivalis, revealing its structure and mechanism for nutrient uptake from the extracellular environment.

Controller for microfluidic large-scale integration

The paper introduces KATARA, an open-source Arduino-based controller for microfluidic devices, enabling precise control of 70 solenoid valves without programming expertise.

The somatically generated T cell receptor CDR3a contributes to the MHC allele specificity of the T cell receptor

The paper shows that the somatically generated CDR3a of T cell receptors influences MHC allele specificity during positive selection.