Author

S. Tsai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 2 Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2

Frequent Co-Authors

E. Y.-C. Chang· 2 shared Y. Huang· 2 shared A. Ali· 1 shared A. Das· 1 shared A. E. Patterson· 1 shared A. J. Gehring· 1 shared A. Karsan· 1 shared A. Kumar· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCell Biology

E. Y.-C. Chang

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

B Cells Promote T Cell Immunosenescence and Mammalian Aging Parameters

S. Khan, M. Chakraborty, F. Wu, N. Chen, T. Wang, Y. T. Chan, A. Sayad, J.-D. S. Vasquez, M. Kotlyar, K. Nguyen, Y. Huang, F. J. Alibhai, M. Woo, R.-K. Li, M. Husain, , D. A. Winer

The paper identifies B cells as drivers of T cell immunosenescence and aging, showing that targeting B cells with CD20 antibodies can reverse age-related T cell dysfunction.

bioRxiv · Sep 12, 2023 · PreprintImmunology

Inducing an oxidized redox-balance improves anti-tumor CD8+ T cell function

J. H. Oh, R. A. Cederberg, L. Bopp, E. Tanaka, T. Ser, S. Niyyati, A. E. Patterson, N. Amanat, J. Dutra, P. Ye, M. Clark, K. Ward-Hartstonge, A.-S. Archambault, J. Tsui, P. F. Lange, , R. I. K. Geltink

This study shows that inducing an oxidized redox balance in CD8+ T cells enhances their anti-tumor function in vivo through increased mitochondrial ROS.

bioRxiv · Mar 27, 2023 · PreprintImmunology

Refined novel techniques for long term cryo-storage using vitrification and laser warming

C. Lin, W.-C. Hsieh, K. Loeslakwiboon, C.-L. Huang, T.-C. Chen, S. Tsai

The paper develops a customized cryo-jig for improved laser striking accuracy and rewarming success in long-term cryo-storage using vitrification and laser warming.

bioRxiv · Jan 4, 2023Bioengineering

A quiescent resident progenitor pool is the central organizer of tendon healing

M. Grinstein, S. Tsai, D. Montoro, H. Dingwall, K. Zou, M. Sade-Feldman, M. Tanaka, T. D. Capellini, J. Rajagopal, J. L. Galloway

This study identifies Axin2+ tenocytes as quiescent progenitors critical for tendon healing, showing they activate and organize repair after injury.

bioRxiv · Feb 2, 2022Cell Biology

Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression

K. Mueller, N. Piscopo, M. Forsberg, L. Saraspe, A. Das, B. Russell, M. Smerchansky, L. Shi, K. Shankar, A. Ali, C. Lazzarotto, S. Tsai, C. M. Capitini, K. Saha

This study produces and tests virus-free CRISPR-CAR T cells that effectively regress solid tumors in vivo.

bioRxiv · Aug 6, 2021Bioengineering

DYNLL1 mis-splicing is associated with replicative genome instability in SF3B1 mutant cells

A. S. Tam, S. Tsai, E. Y.-C. Chang, V. Mathew, A. Shanks, T. R. Docking, A. Kumar, D. G. Bernard, A. Karsan, P. C. Stirling

This study shows SF3B1 mutations cause DYNLL1 mis-splicing, leading to genome instability through altered DNA repair and PARP inhibitor sensitivity.

bioRxiv · May 26, 2021 · PreprintCell Biology

ARID1A regulates R-loop associated DNA replication stress

P. Stirling, S. Tsai, E. Y.-C. Chang, L.-A. Fournier, J. P. Wells, S. W. Minaker, Y. D. Zhu, A. Y.-H. Wang, Y. Wang, D. G. Huntsman

This study shows that ARID1A loss causes DNA replication stress linked to R-loops and transcription-replication conflicts in human cells.

bioRxiv · Nov 16, 2020Cell Biology

Detection of Chemotherapy-Resistant Pancreatic Cancer Using a Glycan Biomarker

C. Gao, L. Wisniewski, Y. Liu, B. Staal, I. Beddows, D. Plenker, M. Aldakkak, J. Hall, D. Barnett, M. Kheir Gouda, P. Allen, R. Drake, A. Zureikat, Y. Huang, D. Evans, , B. Haab

This paper identifies sTRA as a glycan biomarker for chemotherapy-resistant pancreatic cancer, showing its presence correlates with poor treatment response in multiple systems.

bioRxiv · Jun 1, 2020 · PreprintCancer Biology