Author

L.-Y. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

S. Wang· 2 shared A. M. Jadhav· 1 shared B. Chatterjee· 1 shared C. G. Parker· 1 shared C. L. Wang· 1 shared C. Luke· 1 shared C. Spina· 1 shared C. Y. Demirkale· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCell Biology

S. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α

S. Wang, K. S. Awad, L.-Y. Chen, M. A. H. Siddique, G. A. Ferreyra, C. L. Wang, T. Joseph, Z.-X. Yu, K. Takeda, C. Y. Demirkale, Y. Zhao, J. M. Elinoff, R. L. Danner

bioRxiv · Feb 1, 2024Cell Biology

Long-term Hematopoietic Transfer of the Anti-Cancer and Lifespan-Extending Capabilities of A Genetically Engineered Blood System by Transplantation of Bone Marrow Mononuclear Cells

J.-P. Wang, C.-H. Hung, Y.-H. Liou, C.-C. Liu, K.-H. Yeh, K.-Y. Wang, Z.-S. Lai, B. Chatterjee, T.-C. Hsu, T.-L. Lee, Y.-C. Shyu, P.-W. Hsiao, L.-Y. Chen, T.-J. Chuang, C.-H. A. Yu, , C.-K. J. Shen

This study shows that bone marrow mononuclear cells from genetically engineered mice can transfer anti-cancer and lifespan-extending properties to wild-type mice.

bioRxiv · Apr 21, 2023Cancer Biology

SCCA1/SERPINB3 promotes suppressive immune environment via STAT-dependent chemokine production, blunting the therapy-induced T cell responses

S. Markovina, L.-Y. Chen, V. Shi, S. Wang, R. Freeman, F. Ruiz, K. Jayachandran, J. Zhang, P. Cosper, L. Sun, C. Luke, C. Spina, P. Grigsby, J. Schwarz

This study shows that SCCA1/SERPINB3 promotes an immunosuppressive tumor microenvironment by increasing chemokine production via STAT signaling, reducing T cell responses to radiotherapy.

bioRxiv · Feb 1, 2023 · PreprintCancer Biology

Targeted Protein Acetylation in Cells Using Heterobifunctional Molecules

W. W. Wang, L.-Y. Chen, J. Wozniak, A. M. Jadhav, H. Anderson, T. Malone, C. G. Parker

This paper introduces AceTAG, a system to induce targeted protein acetylation in cells, demonstrating its rapid, selective, and controllable nature for various proteins.

bioRxiv · Jul 27, 2021Biochemistry