Author

C. Spina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Obradovic· 1 shared B. Izar· 1 shared C. G. Drake· 1 shared C. Luke· 1 shared C. R. Ager· 1 shared F. Ruiz· 1 shared J. C. Melms· 1 shared J. Schwarz· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

A. Obradovic

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

SCCA1/SERPINB3 promotes suppressive immune environment via STAT-dependent chemokine production, blunting the therapy-induced T cell responses

S. Markovina, L.-Y. Chen, V. Shi, S. Wang, R. Freeman, F. Ruiz, K. Jayachandran, J. Zhang, P. Cosper, L. Sun, C. Luke, C. Spina, P. Grigsby, J. Schwarz

This study shows that SCCA1/SERPINB3 promotes an immunosuppressive tumor microenvironment by increasing chemokine production via STAT signaling, reducing T cell responses to radiotherapy.

bioRxiv · Feb 1, 2023 · PreprintCancer Biology

KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response

C. R. Ager, M. Zhang, M. Chaimowitz, S. Bansal, A. Obradovic, M. Rogava, J. C. Melms, P. McCann, C. Spina, C. G. Drake, M. C. Dallos, B. Izar

The paper identifies KLRG1-expressing CD4 T cell subsets linked to tumor progression and immunotherapy response using longitudinal flow cytometry and machine learning.

bioRxiv · Jan 1, 2023Immunology