Author

F. Ruiz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Organism:mouse· 1

Frequent Co-Authors

C. I. Stoddard· 2 shared H. Y. Chu· 2 shared J. Guenthoer· 2 shared J. Overbaugh· 2 shared M. Lilly· 2 shared V. Chohan· 2 shared A. Finzi· 1 shared B. Dadonaite· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

C. I. Stoddard

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Author profile →

3 papers

Recent·Most cited

The S2 subunit of spike encodes diverse targets for functional antibody responses to SARS-CoV-2

J. Guenthoer, M. E. Garrett, M. Lilly, D. M. Depierreux, F. Ruiz, M. Chi, C. I. Stoddard, V. Chohan, K. Sung, D. Ralph, H. Y. Chu, F. A. Matsen, J. Overbaugh

This paper identifies diverse functional antibodies targeting the S2 subunit of SARS-CoV-2 spike, including one with broad neutralization activity across multiple coronaviruses.

bioRxiv · Feb 26, 2024 · PreprintImmunology

SCCA1/SERPINB3 promotes suppressive immune environment via STAT-dependent chemokine production, blunting the therapy-induced T cell responses

S. Markovina, L.-Y. Chen, V. Shi, S. Wang, R. Freeman, F. Ruiz, K. Jayachandran, J. Zhang, P. Cosper, L. Sun, C. Luke, C. Spina, P. Grigsby, J. Schwarz

This study shows that SCCA1/SERPINB3 promotes an immunosuppressive tumor microenvironment by increasing chemokine production via STAT signaling, reducing T cell responses to radiotherapy.

bioRxiv · Feb 1, 2023 · PreprintCancer Biology

Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection

J. Guenthoer, M. Lilly, T. N. Starr, B. Dadonaite, K. N. Lovendahl, J. T. Croft, C. I. Stoddard, V. Chohan, S. Ding, F. Ruiz, M. S. Kopp, A. Finzi, J. D. Bloom, H. Y. Chu, K. K. Lee, J. Overbaugh

This study identifies four broad, potent monoclonal antibodies against SARS-CoV-2 spike protein that neutralize multiple variants, including Omicron and XBB.1.5, targeting conserved regions with high functional constraint.

bioRxiv · Dec 15, 2022 · PreprintImmunology