BiophysicsbioRxiv
Preferential interactions of a crowder protein with the specific binding site of a native protein complex
X. Dong, L.-Y. Qin, Z. Gong…·C. Tang
This paper investigates how crowder proteins affect the binding affinity and kinetics of the EIN-HPr protein complex using NMR and atomistic modeling, revealing preferential interactions that destabilize the complex.
DOI 10.1021/acs.jpclett.1c03794