Li Wang

The paper uses scATAC-seq to analyze chromatin accessibility in immune cell development and tumor microenvironments, identifying regulatory elements and trajectories associated with cell differentiation and therapy response.

This study identifies TGF-β1 signaling's role in chromatin remodeling that drives glycolysis in pathogenic TH17 cells through epigenetic regulation of metabolic regulators.

This study compares the effects of PaiTeLing, imiquimod, and interferon-α-2b on HPV-infected tissue in nude mice, finding enhanced immune responses with imiquimod and PaiTeLing.

This study shows ET-1 secreted by endothelial cells in ETBR-/- mice worsens diabetic nephropathy by promoting mesangial cell proliferation and ECM accumulation through NF-kappaB and RhoA/ROCK pathways.

The paper validates two lipid-associated expression quantitative trait loci variants using CRISPR-Cas9 and functional assays.

The paper examines how recent demographic changes in maize affect linked selection, finding reduced purifying selection during domestication and stronger purifying selection in young alleles due to population expansion.

This study uses deep mutational scanning to show that fitness landscapes of a kinase depend on antibiotic structure and concentration, enabling the design of variants with orthogonal substrate specificities.