M. A. Herzik

CryoEM Structures of the Nitrogenase Complex During Catalytic Turnover

High-resolution cryoEM structures of the nitrogenase complex obtained under turnover provide new mechanistic insights.

Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution

The paper evaluates cryo-EM model quality using benchmark maps, showing high accuracy and reproducibility across 13 teams and recommending multiple metrics for model assessment.

Sub-2 A Resolution Structure Determination Using Single-Particle Cryo-EM at 200 keV

This study shows that a 200 keV cryo-EM microscope can achieve 1.7 Å resolution for macromolecular structures, comparable to higher voltage systems.

High-resolution structure determination of sub-100 kilodalton complexes using conventional cryo-EM

The paper demonstrates that conventional cryo-EM can determine high-resolution structures of sub-100 kDa complexes, resolving ligands and conformational states with sub-nanometer precision.

Conformational ensemble of the human TRPV3 ion channel

The paper presents cryo-EM structures of human TRPV3 in different states to elucidate its sensitization and gating mechanisms.

Achieving Better Than 3 A Resolution By Single Particle Cryo-EM At 200 keV

This paper shows that 200 keV TEMs can achieve cryo-EM resolutions better than 3 Å, enabling detailed structural analysis previously thought possible only with 300 keV TEMs.

A multi-model approach to assessing local and global cryo-EM map quality

The paper presents a multi-model approach to assess local and global cryo-EM map quality using independent model generation and convergence analysis.