MicrobiologybioRxivPreprint
Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in Mycobacterium tuberculosis
K. Rahman, M. Jamal, X. Chen…·G. Cao
This paper reprograms the endogenous CRISPR-Cas10 system in Mycobacterium tuberculosis for efficient gene editing, RNA interference, and genome-wide screening, enabling functional genomics studies and drug/vaccine development.
DOI 10.1101/2020.03.09.983494