G. Cao

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Ancient DNA in Lycoptera Fossils: Key Discoveries for Evolution and Methodological Reassessment

The paper extracts and analyzes ancient DNA from Lycoptera davidi fossils, identifies original DNA fragments, and introduces a new method for aDNA analysis and a novel genomic mechanism.

A non-invasive, fast on/off 'Odourgenetic' Method to Manipulate Physiology

This paper introduces an Odourgenetic method using Drosophila odorant receptors to non-invasively and rapidly manipulate cellular functions and behavior through inhalation of 2-pentanone.

Phosphatidylethanolamine facilitates mitochondrial pyruvate entry to regulate metabolic flexibility

This study identifies phosphatidylethanolamine's role in regulating mitochondrial pyruvate entry, linking it to metabolic flexibility in skeletal muscle.

Isometric Spiracular Scaling in Scarab Beetles: Implications for Diffusive and Advective Oxygen Transport

This study examines the scaling of spiracles in scarab beetles, finding that diffusive capacities scale isometrically but require higher oxygen gradients in larger species, while advective capacities match respiratory demands during activity.

Microbial dysbiosis and metabolic disorders promote rheumatoid arthritis across successive stages: a multi-omics cohort study

This study identifies stage-specific microbial and metabolic changes in RA progression using multi-omics data from a cohort of patients.

LPS-TLR4 pathway exaggerates alcohol-induced acute-on-chronic liver failure via provoking NETs formation

This study shows that the LPS-TLR4 pathway promotes NETs formation in AACLF, exacerbating liver injury through mechanisms involving gut-derived LPS and neutrophil activity.

Modularity and selection of nectar traits in the evolution of the selfing syndrome in Ipomoea lacunosa (Convolvulaceae)

The paper examines nectar trait evolution in selfing syndrome of Ipomoea lacunosa, finding independent genetic modules for nectar and floral size traits with directional selection on nectar.

Spike Protein Targeting "Nano-Glue" that Captures and Promotes SARS-CoV-2 Elimination

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

Resurrection of human endogenous retroviruses during aging reinforces senescence

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

GENETIC ARCHITECTURE OF DIVERGENCE: THE SELFING SYNDROME IN IPOMOEA LACUNOSA

This study investigates the genetic architecture of the selfing syndrome in Ipomoea lacunosa by analyzing phenotypic correlations and QTL overlaps in F2 offspring, finding that traits cluster into modules with strong within-module correlations.

Transferrin receptor (Tfr1) ablation in satellite cells impacts skeletal muscle regeneration through the activation of ferroptosis

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in Mycobacterium tuberculosis

This paper reprograms the endogenous CRISPR-Cas10 system in Mycobacterium tuberculosis for efficient gene editing, RNA interference, and genome-wide screening, enabling functional genomics studies and drug/vaccine development.

Dscam homophilic specificity is generated by high order cis-multimers coupled with trans self-binding of variable Ig1 in Chelicerata

The paper shows that Dscam isoforms in Chelicerata form cis-multimers and trans-self-bind via Ig1 domains to generate unique homophilic recognition specificities for neuronal self-avoidance.

Large-scale Analysis of 2,152 dataset reveals key features of B cell biology and the antibody repertoire

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

Lesions of canine prostate underwent laser ablation, radiofrequency ablation, and microwave ablation: Lesions shapes and clinical significances

This study compares the shapes and sizes of prostate lesions in dogs treated with laser, radiofrequency, and microwave ablation, finding significant differences in lesion morphology and volume.

TCR-pMHC bond length controls TCR ligand discrimination

This study shows that TCR-pMHC bond length controls TCR ligand discrimination by affecting CD3ζ ITAM phosphorylation and downstream signaling.

Comparison of antioxidant activity between cyanidin-3-O-glucoside (C3G) liposome and cyanidin-3-O-glucoside (C3G) in 2D and 3D cell cultures

This study compares the antioxidant activity of C3G and C3G liposomes in 2D and 3D cell cultures, finding greater effects in the 3D model.