A Coiled-Coil-Based Design Strategy for the Thermostabilization of G-Protein-Coupled Receptors
M. Amer, D. Frey, X. A. Li, R. A. Kammerer
This paper describes a coiled-coil-based strategy to stabilize GPCRs, showing that thermostable variants can be expressed and crystallized, though crystal quality was insufficient for structure determination.
bioRxiv · Mar 28, 2022 · PreprintBiophysics