SUMOylation of PTEN promotes DNA end resection through directly dephosphorylating 53BP1 in homologous recombination repair
J. He, Y. Guo, R. Deng, L. Li, C. Huang, R. Chen, Y. Wang, J. Huang, J. Cheng, G.-Q. Chen, J. Zheng, X. Zhao, J. Yu
This study shows SUMOylation of PTEN enhances HR repair by dephosphorylating 53BP1, promoting DNA end resection and inhibiting NHEJ.
bioRxiv · Feb 6, 2023 · PreprintCell Biology