TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli
H. Yu, S. Lu, K. Gasior, D. Singh, O. Tapia, S. Vazquez-Sanchez, D. Toprani, M. Beccari, J. R. Yates, S. Da Cruz, J. Newby, M. Larfaga, A. Gladfelter, E. Villa, D. W. Cleveland
The paper shows acetylation of TDP-43 drives its phase separation into intranuclear spherical annuli with liquid properties, regulated by HSP70 chaperone activity and proteasome function.
bioRxiv · Mar 28, 2020 · PreprintCell Biology