Cell BiologybioRxivPreprint
TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli
H. Yu, S. Lu, K. Gasior…·D. W. Cleveland
The paper shows acetylation of TDP-43 drives its phase separation into intranuclear spherical annuli with liquid properties, regulated by HSP70 chaperone activity and proteasome function.
DOI 10.1101/2020.03.28.985986