Author

O. Tapia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

J. R. Yates· 2 shared L. Gerace· 2 shared A. Gladfelter· 1 shared A. Shah· 1 shared C. Boogerd· 1 shared C. Lindsay· 1 shared D. Hodzic· 1 shared D. Singh· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

J. R. Yates

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3 papers

Recent·Most cited

Lem2 is essential for cardiac development by maintaining nuclear integrity

J. Ross, N. Arcos-Villacis, E. Battey, C. Boogerd, E. Marhuenda, D. Hodzic, F. Prin, T. Mohun, N. Catibog, O. Tapia, L. Gerace, T. Iskratsch, A. Shah, M. Stroud

This study shows Lem2 is essential for cardiac development by maintaining nuclear integrity, as its absence leads to DNA damage, nuclear rupture, and apoptosis in mouse hearts.

bioRxiv · Feb 10, 2022Cell Biology

TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli

H. Yu, S. Lu, K. Gasior, D. Singh, O. Tapia, S. Vazquez-Sanchez, D. Toprani, M. Beccari, J. R. Yates, S. Da Cruz, J. Newby, M. Larfaga, A. Gladfelter, E. Villa, D. W. Cleveland

The paper shows acetylation of TDP-43 drives its phase separation into intranuclear spherical annuli with liquid properties, regulated by HSP70 chaperone activity and proteasome function.

bioRxiv · Mar 28, 2020 · PreprintCell Biology

Identification of new transmembrane proteins concentrated at the nuclear envelope using organellar proteomics of mesenchymal cells

L.-C. Cheng, S. Baboo, C. Lindsay, L. E. Brusman, S. Martinez-Bartolome, O. Tapia, X. Zhang, J. R. Yates, L. Gerace

The paper identifies five new transmembrane proteins enriched at the nuclear envelope in mesenchymal cells using proteomics and immunofluorescence validation.

bioRxiv · Dec 3, 2018Cell Biology