Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
A. Pickard, R. Garva, A. D. Adamson, B. C. Calverley, A. Hoyle, C. Hayward, D. Spiller, Y. Lu, N. W. Hodson, O. Mandolfo, K. Kim, G. Bou-Charios, J. Swift, B. Bigger, K. E. Kadler
The paper investigates collagen fibril formation in fibroblasts, showing it occurs at the plasma membrane independently of secretion and involves endocytosis.
bioRxiv · May 9, 2024Cell Biology
A. Pickard, F. Amoroso, K. McCulloch, A. Erickson, A. Sachdeva, R. Steele, D. Mukherjee, M. Dellett, J. McComb, L. McCaffrey, C. Hart, M. Brown, S. S. McDade, D. Waugh, N. Clarke, , I. Mills
This study investigates how IRF7 influences prostate cancer cell survival after radiation and identifies therapeutic vulnerabilities linked to IRF7 expression.
bioRxiv · Sep 23, 2022 · PreprintCancer Biology
P. Dancer, A. Pickard, W. Potocka, K. Earle, R. Fortune-Grant, K. Kadler, M. Bertuzzi, S. Gago
This study shows that viral and fungal infections inhibit each other's clearance by airway epithelial cells during coinfection, promoting disease severity.
bioRxiv · Apr 13, 2022 · PreprintMicrobiology
C.-Y. C. Yeung, R. Garva, A. Pickard, Y. Lu, V. Mallikarjun, J. Swift, S. H. Taylor, J. Rai, D. R. Eyre, M. Chaturvedi, Y. Itoh, Q.-J. Meng, C. Mauch, P. Zigrino, K. E. Kadler
This study shows that Mmp14 regulates circadian rhythms and matrisome homeostasis in tendon fibroblasts by controlling collagen fibril synthesis and crosslinking.
bioRxiv · Apr 1, 2022Cell Biology
J. CHANG, A. PICKARD, J. A. Herrera, S. O'Keefe, M. Hartshorn, R. GARVA, A. Hoyle, L. Dingle, C. Zeltz, J. Wong, A. Reid, R. V. Venkateswaran, Y. Lu, P. Caswell, S. High, , K. E. KADLER
This study shows that circadian-regulated endocytic recycling is essential for collagen fibril assembly and is disrupted in fibrosis.
bioRxiv · Mar 25, 2021Cell Biology
A. Pickard, B. C. Calverley, J. Chang, R. Garva, Y. Lu, K. E. Kadler
This study identifies 35 FDA-approved drugs that reduce SARS-CoV-2 replication in human cells, including amodiaquine and vitamin D3.
bioRxiv · Jan 31, 2021Immunology
B. C. Calverley, K. Kadler, A. Pickard
This paper introduces DyProQ, a method using CRISPR-Cas9 and NanoLuciferase to quantify procollagen-I dynamically, identifying potential drug candidates for fibrotic and degenerative diseases.
bioRxiv · May 17, 2020Cell Biology
C. Haughey, D. Mukherjee, R. Steele, A. Popple, L. Dura-Perez, A. Pickard, S. Jain, P. Mullan, R. Williams, P. Oliveira, N. Buckley, J. Honeychurch, S. S. McDade, T. Illidge, I. Mills, S. Eddie
This paper develops a novel allograft model of high-risk prostate cancer that mimics human disease features and responds to radiotherapy.
bioRxiv · Feb 16, 2020 · PreprintCancer Biology
J. Chang, R. Garva, A. Pickard, C.-Y. C. Yeung, V. Mallikarjun, J. Swift, D. F. Holmes, B. Calverley, Y. Lu, A. Adamson, H. Raymond-Hayling, O. Jensen, T. Shearer, Q. J. Meng, K. E. Kadler
The paper identifies a circadian mechanism regulating collagen synthesis, assembly, and degradation to maintain tissue homeostasis in mice.
bioRxiv · Apr 7, 2019Cell Biology
A. Pickard, J. Chang, N. Alachkar, B. Calverley, R. Garva, P. Arvan, Q. J. Meng, K. E. Kadler
The paper shows that BiP and chemical chaperones strengthen circadian rhythms in fibroblasts under ER stress and prevent ER stress in tendon by regulating collagen synthesis.
bioRxiv · Oct 4, 2018Cell Biology