M. Cooper

Structural basis for allosteric regulation of human phosphofructokinase-1

This study determines the cryoEM structures of human PFK1 in R- and T-states, revealing eukaryotic allosteric regulation mechanisms and the role of the C-terminus in autoinhibition.

A comprehensive evaluation of taxonomic classifiers in marine vertebrate eDNA studies

This study evaluates nine taxonomic classifiers for marine vertebrate eDNA studies, finding MMSeqs2 and Metabuli outperform BLAST in accuracy and reducing false positives.

GroEL-proteotyping of bacterial communities by tandem mass spectrometry

The paper introduces GroEL-proteotyping, a method using tandem mass spectrometry to profile bacterial communities at the family level, validated on synthetic and human gut samples.

Small extracellular vesicles but not microvesicles from Opisthorchis viverrini promote cell proliferation in human cholangiocytes.

This study identifies that specific extracellular vesicles from Opisthorchis viverrini promote human cholangiocyte proliferation, suggesting a role in cholangiocarcinoma development.

Intranasal VLP-RBD vaccine adjuvanted with BECC470 confers immunity against Delta SARS-CoV-2 challenge in K18-hACE2-mice

This study shows an intranasal VLP-RBD vaccine with BECC470 adjuvant provides protection against Delta SARS-CoV-2 in mice, with mucosal immunity and reduced lung inflammation.

Root system growth and function response to soil temperature in maize (Zea mays L.)

This study investigates genetic variation in maize root growth and water transport under low temperatures and shows their contribution to drought tolerance and yield variation.

Transgene by Germplasm Interactions Can Impact Transgene Evaluation

This study evaluates how genetic background affects transgene performance in maize, finding variable yield impacts across different hybrid combinations.

Methods for Evaluating Effects of Transgenes for Quantitative Traits

This study evaluates three methods for estimating transgene effects across genetic backgrounds and environments, finding that bulked F3 lines topcrossed to a tester inbred provide the most effective approach.

Plant Breeding in the face of climate change

The paper proposes a framework for breeding crops adapted to climate change by integrating genomic, agronomic, and environmental predictors to predict phenotypes and identify effective G x M technologies.

Physiological trait networks enhance understanding of crop growth and water use in contrasting environments

The paper uses a process-based model to identify contrasting trait networks in maize that enhance growth and water use in different environments.

Predicting phenotypes from genetic, environment, management, and historical data using CNNs

This paper uses CNNs to predict phenotypes from genetic, environmental, and management data, showing improved accuracy with pre-training on historical data.

Modelling Human Gait using a Nonlinear Differential Equation

The paper models human gait using a nonlinear differential equation based on 3D visualization of center of mass movement during walking or running.

Can we harness digital technologies and physiology to hasten genetic gain in U.S. maize breeding?

This study uses digital technologies and physiology to improve genetic gain in maize breeding by enhancing predictive models and breeding objectives.

Two decades of creating drought tolerant maize and underpinning prediction technologies in the US corn-belt: Review and perspectives on the future of crop design

This paper reviews drought tolerant maize breeding efforts and shows increased crop improvement rates, suggesting future crop design through integrated prediction technologies.

Reproductive resilience but not root architecture underpin yield improvement in maize

This study shows that yield improvement in maize is driven by reproductive resilience rather than changes in root architecture or water capture.

Microbial subnetworks related to short-term diel O2 fluxes within geochemically distinct freshwater wetlands

The paper examines how microbial communities in freshwater wetlands respond to diel O2 fluctuations, finding that while overall communities are stable, specific subcommunities correlate with O2 levels.

Octapeptin C4 Induces Less Resistance and Novel Mutations in an Epidemic Carbapenemase-producing Klebsiella pneumoniae ST258 Clinical Isolate Compared to Polymyxins

This study compares resistance development in XDR Klebsiella pneumoniae ST258 exposed to polymyxins and octapeptin C4, finding OctC4 induces less resistance and novel mutations.