Geometric constraint of mechanosensing in bone marrow stromal cell cultures prevents stiffness-induced differentiation
M. L. Hernandez-Miranda, D. Xu, D. A. Johnston, M. Browne, R. B. Cook, B. G. Sengers, N. D. Evans
This study shows that in bone marrow stromal cells, matrix deformations and differentiation are influenced by ECM stiffness, geometry, and cell density, with high cell density reducing deformation differences between stiff and soft substrates.
bioRxiv · Oct 5, 2023 · PreprintBiophysics