Author

M. C. Blaser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

E. Aikawa· 4 shared T. Pham· 3 shared C. L. Clift· 2 shared M. Aikawa· 2 shared M. E. Turner· 2 shared S. A. Singh· 2 shared A. C. Sonawane· 1 shared A. Pang· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersCell Biology

E. Aikawa

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve disease

F. Bartoli-Leonard, S. Chelvanambi, T. Pham, M. E. Turner, M. C. Blaser, M. Caputo, M. Aikawa, A. Pang, J. Muehlschlegel, E. Aikawa

The paper uses single-cell T cell receptor sequencing to analyze paired tissue and blood samples from CAVD patients, identifying clonal expansion of CD8+ effector T cells and potential epitope targets in the valve.

bioRxiv · Jul 8, 2023 · PreprintImmunology

Intracellular Proteomics and Extracellular Vesiculomics as a Metric of Disease Recapitulation in 3D Bioprinted Aortic Valve Arrays

C. L. Clift, M. C. Blaser, W. Gerrits, M. E. Turner, A. C. Sonawane, T. Pham, J. L. Andresen, O. S. Fenton, J. M. Grolman, F. Buffolo, F. J. Schoen, J. Hjortnaes, J. D. Muehlschlegel, D. D. Mooney, M. Aikawa, , E. Aikawa

This study compares 3D-bioprinted and 2D models of calcific aortic valve disease using proteomics and vesiculomics to assess disease recapitulation.

bioRxiv · Jun 22, 2023Bioengineering

Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall

S. Raju, S. R. Botts, M. C. Blaser, K. Prajapati, T. W. W. Ho, C. Ching, N. J. Galant, L. Fiddes, R. Wu, C. L. Clift, T. Pham, W. L. Lee, S. A. Singh, E. Aikawa, J. E. Fish, K. L. Howe

This study shows endothelial cells release distinct extracellular vesicles to reprogram monocytes and smooth muscle cells in circulation and vessel wall.

bioRxiv · Apr 28, 2023 · PreprintCell Biology

Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling

U. Majumdar, S. Manivannan, M. Basu, Y. Ueyama, M. C. Blaser, E. Cameron, M. R. McDermott, J. Lincoln, S. E. Cole, S. Wood, E. Aikawa, B. Lilly, V. Garg

The paper shows nitric oxide prevents aortic valve calcification by S-nitrosylating USP9X to activate NOTCH signaling in porcine valve cells and mice.

bioRxiv · Aug 15, 2020Cell Biology