M. Caputo

Altered inflammatory state and mitochondrial function identified by transcriptomics in paediatric congenital heart patients prior to surgical repair

This study identifies altered mitochondrial function and increased inflammatory T cell markers in paediatric CHD patients before surgery using transcriptomic analysis of RV biopsies.

Phospholipid Scramblase-1 is required for efficient neurotransmission and synaptic vesicle retrieval at cerebellar synapses

This study shows that PLSCR1 is essential for synaptic vesicle retrieval and neurotransmission by regulating phospholipid asymmetry at cerebellar synapses.

Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve disease

The paper uses single-cell T cell receptor sequencing to analyze paired tissue and blood samples from CAVD patients, identifying clonal expansion of CD8+ effector T cells and potential epitope targets in the valve.

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

This paper shows that SARS-CoV-2 Spike protein causes cardiac pericyte dysfunction through CD147-mediated signaling, without infecting the cells.

Contractile reprogramming of cardiac pericytes by MEK inhibition promotes arteriologenesis of the ischemic heart

This study shows that MEK inhibition reprograms cardiac pericytes into contractile cells, promoting arteriologenesis in ischemic hearts.

Maternal phylogenetic relationships and genetic variation among rare similar phenotype donkey breeds

The paper analyzes mtDNA sequencing of four rare donkey breeds to assess genetic diversity and phylogenetic relationships, finding high variability in some breeds and highlighting conservation needs.