Author

C. Ching

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:E. coli· 2 Organism:human· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

I. Sutradhar· 3 shared M. H. Zaman· 3 shared A. S. Khalil· 2 shared D. Desai· 2 shared Z. Heins· 2 shared A. A. Hyman· 1 shared A. M. Knight· 1 shared A. Reverdy· 1 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersBioengineering

I. Sutradhar

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Evolving a High-Performance Terminal Deoxynucleotidyl Transferase for Enzymatic DNA Synthesis

S. Forget, M. Krawczyk, A. M. Knight, C. Ching, R. Copeland, N. Mahmoodi, M. Mayo, J. Nguyen, A. Tan, M. G. Miller, J. Vroom, S. Lutz

This paper evolves a terminal deoxynucleotidyl transferase for enzymatic DNA synthesis using modified substrates, showing improved activity, template promiscuity, and thermostability.

bioRxiv · Jun 24, 2024 · PreprintBioengineering

RecA levels modulate biofilm development in Acinetobacter baumannii

C. Ching, M. Brychcy, B. Nguyen, P. Muller, A. Reverdy, M. Downs, S. Regan, B. Isley, W. Fowle, Y. Chai, V. G. Godoy

This study shows that varying RecA levels in Acinetobacter baumannii affect biofilm formation and dispersal through the regulator bfmR, highlighting the role of DDR in infection persistence.

bioRxiv · May 10, 2023 · PreprintMicrobiology

Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall

S. Raju, S. R. Botts, M. C. Blaser, K. Prajapati, T. W. W. Ho, C. Ching, N. J. Galant, L. Fiddes, R. Wu, C. L. Clift, T. Pham, W. L. Lee, S. A. Singh, E. Aikawa, J. E. Fish, K. L. Howe

This study shows endothelial cells release distinct extracellular vesicles to reprogram monocytes and smooth muscle cells in circulation and vessel wall.

bioRxiv · Apr 28, 2023 · PreprintCell Biology

Impact of Zinc Pre-exposure on de novo Antibiotic Resistance Development

M. P. Suprenant, C. Ching, I. Sutradhar, N. Gross, J. E. Anderson, N. El Sherif, M. H. Zaman

This study shows that zinc pre-exposure before ciprofloxacin exposure in E. coli accelerates antibiotic resistance development, while combined exposure delays it, without causing genetic changes.

bioRxiv · Apr 10, 2023 · PreprintMicrobiology

Effects of Antibiotic Interaction on Antimicrobial Resistance Development in Wastewater

I. Sutradhar, C. Ching, D. Desai, Z. Heins, A. S. Khalil, M. H. Zaman

This study investigates how antibiotic interactions in wastewater affect antimicrobial resistance development in E. coli, finding that synergistic interactions suppress resistance while antagonistic interactions show ratio-dependent resistance development.

bioRxiv · Feb 10, 2023Bioengineering

Molecular mechanisms of stress-induced reactivation in mumps virus condensates

X. Zhang, S. Sridharan, I. Zagoriy, C. Eugster Oegema, C. Ching, T. Pflaesterer, H. K. H. Fung, I. Poser, C. W. Mueller, A. A. Hyman, M. M. Savitski, J. Mahamid

The paper investigates how cellular stress triggers reactivation of persistent mumps virus infection through molecular and structural changes in viral condensates.

bioRxiv · Jul 10, 2021Cell Biology

Computational Model to Quantify the Growth of Antibiotic Resistant Bacteria in Wastewater

I. Sutradhar, C. Ching, D. Desai, M. Suprenant, E. Briars, Z. Heins, A. S. Khalil, M. H. Zaman

The paper develops a computational model to predict antibiotic resistant bacteria growth in wastewater, finding horizontal gene transfer and antibiotic interactions drive resistance more than chromosomal mutations.

bioRxiv · Oct 9, 2020Bioengineering