E. Aikawa

Multiomics unveils extracellular vesicle-driven mechanisms of endothelial communication in human carotid atherosclerosis

This study identifies EV-driven endothelial communication in human carotid atherosclerosis, showing increased angiogenic activity in symptomatic plaques.

Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve disease

The paper uses single-cell T cell receptor sequencing to analyze paired tissue and blood samples from CAVD patients, identifying clonal expansion of CD8+ effector T cells and potential epitope targets in the valve.

Intracellular Proteomics and Extracellular Vesiculomics as a Metric of Disease Recapitulation in 3D Bioprinted Aortic Valve Arrays

This study compares 3D-bioprinted and 2D models of calcific aortic valve disease using proteomics and vesiculomics to assess disease recapitulation.

Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall

This study shows endothelial cells release distinct extracellular vesicles to reprogram monocytes and smooth muscle cells in circulation and vessel wall.

Porcine and human aortic valve endothelial and interstitial cell isolation and characterization

This study isolates and characterizes human and porcine aortic valve endothelial and interstitial cells, comparing their gene expression and calcification responses.

Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling

The paper shows nitric oxide prevents aortic valve calcification by S-nitrosylating USP9X to activate NOTCH signaling in porcine valve cells and mice.