M. C. Frame

A novel ILK/STAT3 pathway controls plasticity in a neural stem cell model of glioblastoma.

This study identifies a novel ILK-STAT3 pathway that regulates phenotypic plasticity and mesenchymal state in mouse glioblastoma stem cells.

Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer

The paper identifies tumour-specific ECM proteome signatures in NSCLC patients using mass spectrometry, finding 161 differentially regulated matrisome proteins and two novel extracellular markers associated with poorer survival.

Loss of the adhesion protein Kindlin-1 stimulates tumor clearance via modulation of Tregs

This study shows that loss of Kindlin-1 in breast cancer cells reduces tumor growth by decreasing Treg numbers and function, mediated by increased IL-6 secretion.

Characterisation of a nucleo-adhesome

The paper identifies a nucleo-adhesome, showing that adhesion proteins localize to the nucleus and regulate transcription through interactions like FAK and Hic-5.

Mena regulates the LINC complex to control actin-nuclear lamina associations, trans-nuclear membrane signalling and cancer gene expression

This study identifies Mena's role in regulating the LINC complex and nuclear architecture, linking it to cancer gene expression through nuclear membrane signaling.

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors.

This study profiles the effects of the SRC inhibitor AZD0424 in combination with MEK inhibitors, showing reduced compensatory activation and enhanced anti-tumor effects in colorectal cancer models.

Toll-like receptor 2 orchestrates a potent anti-tumor response in non-small cell lung cancer

This study identifies TLR2 as a tumor suppressor in early-stage lung cancer, showing its role in immune surveillance and tumor growth reduction through synthetic agonist administration.

A novel transcriptional signalling pathway mediated by the trafficking protein Ambra1 via scaffolding Atf2 complexes

This study identifies a novel nuclear scaffolding function of Ambra1 that regulates transcriptional signaling by recruiting chromatin modifiers and transcription factors to control gene expression.

A Synergistic Anti-Cancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High Content Phenotypic Screen

The paper identifies a synergistic combination of FAK and HDAC inhibitors using a chemical-genetic high-content screen, showing efficacy in cancer cell lines and in vivo.