Y. Kumar

Phosphoglucomutase A mediated regulation of carbon flux is essential for antibiotic and disease persistence in Mycobacterium tuberculosis

This study shows that phosphoglucomutase A (pgmA) is essential for Mycobacterium tuberculosis survival under nutrient-limiting conditions and disease persistence.

(p)ppGpp and DksA play crucial role in reducing the efficacy of b-lactam antibiotics by modulating bacterial membrane permeability

This study shows that (p)ppGpp and DksA reduce the effectiveness of beta-lactam antibiotics by altering bacterial membrane permeability and peptidoglycan biosynthesis in Vibrio cholerae.

TPR is required for cytoplasmic chromatin fragment formation during senescence

The paper shows TPR is required for early NF-κB activation during oncogene-induced senescence, leading to cytoplasmic chromatin fragment formation and SASP activation.

The ER-resident Ras Inhibitor 1 (Eri1) of Candida albicans inhibits hyphal morphogenesis via the Ras-independent cAMP-PKA pathway

This paper investigates the role of Eri1 in Candida albicans, showing it inhibits hyphal morphogenesis via a Ras-independent cAMP-PKA pathway and affects virulence.

Hypothetical gene Rv0495c regulates redox homeostasis in Mycobacterium tuberculosis

This study identifies Rv0495c as a regulator of redox homeostasis in Mtb, showing that its absence increases ROS and susceptibility to stress, yet enhances pathogenicity in host models.

Fluorogenesis: Inducing Fluorescence in a Non-Fluorescent Protein Through Photoinduced Chromophore Transfer of a Genetically Encoded Chromophore

This paper induces red fluorescence in a non-fluorescent kinase using light-induced chromophore transfer from a photocleavable protein, demonstrating its use as a cyclable high-temperature sensor.

Proinflammatory innate cytokines and metabolomic signatures shape the T cell response in active COVID-19

The paper examines how proinflammatory cytokines and metabolomic signatures influence T cell responses in active COVID-19 patients, showing preserved T cell responses against variants despite reduced antibody responses.

Mena regulates the LINC complex to control actin-nuclear lamina associations, trans-nuclear membrane signalling and cancer gene expression

This study identifies Mena's role in regulating the LINC complex and nuclear architecture, linking it to cancer gene expression through nuclear membrane signaling.

MOV10 facilitates messenger RNA decay in an N6-methyladenosine (m6A) dependent manner to maintain the mouse embryonic stem cells state

The paper identifies MOV10 as a new m6A-reader that facilitates mRNA decay via m6A to regulate the WNT/β-CATENIN pathway and maintain mouse embryonic stem cell state.

Characterization of a novel mesophilic CTP-dependent riboflavin kinase and rational engineering to create its thermostable homologs

This study characterizes a mesophilic CTP-dependent riboflavin kinase from Methanococcus maripaludis and identifies residues responsible for thermostability through comparative analysis and mutagenesis.

Immunological and cardio-vascular pathologies associated with SARS-CoV-2 infection in golden syrian hamster

This study shows that SARS-CoV-2 infection in golden Syrian hamsters causes lung and cardiovascular pathologies similar to human COVID-19, suggesting GSH as a model for studying long-term effects.

Disulfiram inhibits M. tuberculosis growth by altering methionine pool, redox status and host-immune response

This study identifies disulfiram as a novel inhibitor of Mtb's methionine biosynthesis, showing anti-tubercular effects through redox disruption and immune modulation.