Author

M. C. Lechler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

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Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:protein structure· 1

Frequent Co-Authors

D. C. David· 2 shared R. Jung· 2 shared A. D. Stephens· 1 shared C. F. Kaminski· 1 shared C. H. Michel· 1 shared C. Huang· 1 shared C. Poudel· 1 shared C. Rödelsperger· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCell Biology

D. C. David

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintDec 4, 2020

Tissue-specific safety mechanism results in opposite protein aggregation patterns during aging

R. Jung, M. C. Lechler, C. Rödelsperger…·D. C. David

The paper identifies a tissue-specific safety mechanism, SAPA, that suppresses age-dependent protein aggregation in C. elegans pharyngeal muscles but not body-wall muscles.

DOI 10.1101/2020.12.04.409771

C. elegansgenetic perturbation / CRISPR

𝕏 PostBluesky

Cell BiologybioRxivSep 14, 2018

Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in C. elegans

C. Huang, S. Wagner-Valladolid, A. D. Stephens…·D. C. David

This study shows that age-dependent protein aggregation in C. elegans forms amyloid-like structures and accelerates tissue functional decline, suggesting a role for protein aggregation in aging.

DOI 10.7554/elife.43059

C. elegansprotein structure

𝕏 PostBluesky