Author

M. Castets

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

P. Huchede· 3 shared A. Dutour· 2 shared C. Picard· 2 shared J.-Y. Blay· 2 shared K. Weber· 2 shared L. Broutier· 2 shared M. Cordier-Bussat· 2 shared M. Creveaux· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

P. Huchede

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Lysosomal MLKL is balanced by ESCRT to control cell death

C. Jamard, C. Gil, M. Castets, G. Ichim, K. Weber

The paper shows lysosomal MLKL is activated independently of RIPK3 and necroptosis, leading to cell death, which is counteracted by ESCRT machinery through lysosomal repair and sequestration of MLKL.

bioRxiv · Aug 29, 2023 · PreprintCell Biology

Alterations of the TGFb-sequestration complex member ADAMTSL1 levels are associated with muscular defects and rhabdomyosarcoma aggressiveness

A. Bertrand-Chapel, S. Meyer, G. Juban, A. E. M. Kneppers, P. Huchede, C. Gallerne, R. Benayoun, E. Cohen, A. Lopez-Gonzalez, S. B. Larbi, M. Creveaux, L. Vaille, A. Bouvier, M. Theodore, L. Broutier, , M. CASTETS

This study shows ADAMTSL1 is involved in skeletal muscle regeneration and acts as a prognostic factor in aggressive rhabdomyosarcoma, correlating with a neural-like phenotype.

bioRxiv · Mar 7, 2023 · PreprintCancer Biology

Fusion-negative Rhabdomyosarcoma 3D-organoids as an innovative model to predict resistance to cell death inducers

C. Savary, P. Huchede, L. Luciana, A. Tourbez, C. Deligne, C. Picard, T. Diot, C. Coquet, N. Meynard, M. Le Grand, L. Tonon, N. Gadot, C. Degletagne, S. Leon, V. Attignon, , L. Broutier

The paper develops a 3D-organoid model of fusion-negative rhabdomyosarcoma to predict resistance to cell death inducers using omics data.

bioRxiv · Sep 6, 2022 · PreprintCancer Biology

Low expression of ANT1 confers oncogenic properties to rhabdomyosarcoma tumor cells via modulating metabolism and death pathways.

J. Vial, P. Huchede, S. Fagault, F. Basset, M. Rossi, J. Geoffray, J. Bisaccia, M. Creveaux, D. Neves, F. Fauvelle, P. Castets, M. Carre, K. Weber, M. Castets

This study shows that low ANT1 expression in rhabdomyosarcoma cells promotes oncogenic properties by altering metabolism and death pathways, and restoring ANT1 sensitizes cells to chemotherapy.

bioRxiv · Mar 3, 2020Cancer Biology