C. Picard

Low prevalence of HLA-G antibodies in lung transplant patients detected by MAIPA adapted protocol

This study detects low prevalence of HLA-G antibodies in lung transplant recipients using a modified MAIPA assay, suggesting their rarity and potential clinical relevance.

Can higher aggressiveness effectively compensate for a virulence deficiency in plant pathogen? A case study of Puccinia triticina's fitness evolution in a diversified varietal landscape

This study shows that higher aggressiveness can compensate for virulence deficiencies in Puccinia triticina, explaining its competitive advantage over a virulent pathotype in a wheat landscape.

Alterations of the TGFb-sequestration complex member ADAMTSL1 levels are associated with muscular defects and rhabdomyosarcoma aggressiveness

This study shows ADAMTSL1 is involved in skeletal muscle regeneration and acts as a prognostic factor in aggressive rhabdomyosarcoma, correlating with a neural-like phenotype.

Fusion-negative Rhabdomyosarcoma 3D-organoids as an innovative model to predict resistance to cell death inducers

The paper develops a 3D-organoid model of fusion-negative rhabdomyosarcoma to predict resistance to cell death inducers using omics data.

Evolution within a given virulence phenotype (pathotype) is driven by changes in aggressiveness: a case study of French wheat leaf rust populations

The paper shows that changes in aggressiveness drive evolution within a virulence phenotype in French wheat leaf rust populations, with more recent genotypes being more aggressive than older ones.

SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4

This study shows SARS-CoV-2 activates human plasmacytoid pre-dendritic cells (pDC) via UNC93B and IRAK4, leading to interferon and cytokine production.

Heterozygous RELA mutations cause early-onset systemic lupus erythematosus by hijacking the NF-κB pathway towards transcriptional activation of type-I Interferon genes

This study identifies heterozygous RELA mutations in early-onset SLE patients, showing they drive type-I interferon gene expression through NF-κB pathway hijacking.

Arenaviridae exoribonuclease presents genomic RNA edition capacity.

This paper investigates the RNA exonuclease activity of Arenavirus ExoN, showing it edits genomic RNA and links to genome stability rather than innate immune suppression.

Quality control implementation for universal characterization of DNA and RNA viruses in clinical respiratory samples using single metagenomic next-generation sequencing workflow

This paper evaluates a single metagenomic next-generation sequencing workflow for detecting DNA and RNA viruses in clinical respiratory samples, showing high accuracy and correlation with PCR results.