Protein Kinase C Delta Regulates Mononuclear Phagocytes and Hinders Response to Immunotherapy in Cancer
M. Chaib, J. R. Holt, L. M. Sipe, M. S. Bohm, S. C. Joseph, J. Yarbro, U. Tanveer, T. J. Hollingsworth, Q. Wei, P. Thomas, D. N. Hayes, L. Makowski
This study shows that PKCδ in mononuclear phagocytes suppresses antitumor immunity and response to immunotherapy by reprogramming macrophages and dendritic cells.
bioRxiv · Mar 31, 2022Immunology