Author

H.-Y. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 2 Immunology· 2 Microbiology· 2 Plant Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Assay:proteomics· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

G. L. Rogers· 3 shared P. M. Cannon· 3 shared X. Huang· 3 shared C. Huang· 2 shared G. N. Llewellyn· 2 shared A. Almonte-Loya· 1 shared A. D. Yoder· 1 shared A. H. Sabet· 1 shared

Activity by Year

2019-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersMicrobiology

G. L. Rogers

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Exploring Abeta42 Monomer Diffusion Dynamics on Fibril Surfaces through Molecular Simulations

Y.-W. Ma, G.-F. Wang, H.-Y. Chen, M.-Y. Tsai

This study uses molecular simulations to analyze Abeta42 monomer diffusion on fibril surfaces, finding orientation and surface roughness significantly affect diffusion and aggregation.

bioRxiv · Feb 29, 2024Biophysics

Reprogramming human B cells with custom heavy chain antibodies

G. L. Rogers, C. Huang, A. Mathur, X. Huang, H.-Y. Chen, K. Stanten, H. Morales, C.-H. Chang, E. J. Kezirian, P. M. Cannon

This paper describes a genome editing strategy to reprogram human B cells to express custom heavy chain antibodies that respond to immunization.

bioRxiv · Jun 28, 2023Immunology

Comparison of SARS-CoV-2 entry inhibitors based on ACE2 receptor or engineered Spike-binding peptides

G. N. Llewellyn, H.-Y. Chen, G. L. Rogers, X. Huang, P. Sell, J. E. Henley, P. M. Cannon

This study compares ACE2-derived and engineered Spike-binding peptide entry inhibitors against SARS-CoV-2 variants, finding that an optimized ACE2 derivative neutralizes all tested variants, while peptides show variable efficacy with resistance observed in Beta, Gamma, and Omicron variants.

bioRxiv · Jan 5, 2023 · PreprintMicrobiology

Auxin Plays a Role in the Adaptation of Rice to Anaerobic Germination and Seedling Establishment

K.-W. Lee, J. J. W. Chen, C.-S. Wu, H.-C. Chang, H.-Y. Chen, H.-H. Kuo, Y.-S. Lee, Y.-L. Chang, H.-C. Chang, S.-Y. Shiuea, Y.-C. Wu, Y. C. Ho, P.-W. Chen

This study shows that auxin accumulation under submergence inhibits rice root and leaf growth but promotes coleoptile elongation, with miR167-ARF-GH3 pathway regulating IAA levels to affect anaerobic germination tolerance.

bioRxiv · May 5, 2022Plant Biology

Regulation of Neuroendocrine Plasticity by the RNA-Binding Protein ZFP36L1

H.-Y. Chen, Y. T. Durmaz, Y. Li, A. H. Sabet, A. Vajdi, T. Denize, E. Walton, J. G. Doench, N. R. Mahadevan, J. A. Losman, D. A. Barbie, M. Y. Tolstorukov, C. M. Rudin, T. Sen, S. Signoretti, M. Oser

This study identifies ZFP36L1 as an LSD1 target gene that regulates neuroendocrine plasticity in SCLC by destabilizing mRNAs of lineage transcription factors.

bioRxiv · Oct 22, 2021Cancer Biology

Epigenetic Remodeling by Vitamin C Potentiates the Differentiation of Mouse and Human Plasma Cells

H.-Y. Chen, A. Almonte-Loya, F.-Y. Lay, E. Johnson, E. Gonzalez-Avalos, J. Yin, Q. Ma, D. J. Wozniak, F. E. Harrison, C.-W. J. Lio

This study shows vitamin C enhances plasma cell differentiation in mouse and human B cells by epigenetic remodeling via TET enzymes and STAT3-dependent mechanisms.

bioRxiv · Sep 15, 2021 · PreprintImmunology

Mutationathon: towards standardization in estimates of pedigree-based germline mutation rates

L. A. Bergeron, S. Besenbacher, T. N. Turner, C. J. Versoza, R. Wang, A. L. Price, E. Armstrong, M. Riera, J. Carlson, H.-y. Chen, M. W. Hahn, K. Harris, A. S. L. N. M. Kleppe, E. H. Lopez-Nandam, P. Moorjani, , M. H. Schierup

The paper evaluates variation in germline mutation rate estimates across labs using a standardized pedigree of rhesus macaques, highlighting methodological differences and the need for standardization.

bioRxiv · Aug 30, 2021Evolutionary Biology

Cytoplasmic tail truncation of SARS-CoV-2 Spike protein enhances titer of pseudotyped vectors but masks the effect of the D614G mutation

H.-Y. Chen, C. Huang, L. Tian, X. Huang, C. Zhang, G. N. Llewellyn, G. L. Rogers, K. Andresen, M. R. G. O'Gorman, Y.-W. Chen, P. M. Cannon

This study shows that truncating the SARS-CoV-2 Spike protein's cytoplasmic tail increases pseudovector titer but masks the D614G mutation's effect on Spike incorporation.

bioRxiv · Jun 21, 2021Microbiology

Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASmut melanoma

B. Lipchick, A. N. Guterres, H.-Y. Chen, D. M. Zundell, S. Del Aguila, P. I. Reyes-Uribe, S. Basu, X. Yin, A. V. Kossenkov, Y. Lu, G. B. Mills, Q. Liu, A. R. Goldman, M. E. Murphy, D. W. Speicher, J. Villanueva

This study identifies S6K2 as a vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma, showing its abrogation disrupts lipid homeostasis and triggers cell death.

bioRxiv · Apr 7, 2021 · PreprintCancer Biology

Feedback inhibition of AMT1 NH4+-transporters mediated by CIPK15 kinase

H.-Y. Chen, Y.-N. Chen, H.-Y. Wang, Z.-T. Liu, W. B. Frommer, C.-H. Ho

This study identifies CIPK15 as a kinase that inhibits AMT1 ammonium transporters through phosphorylation, reducing NH4+ accumulation in plants.

bioRxiv · Nov 3, 2020Plant Biology

Direct microRNA sequencing using Nanopore Induced Phase-Shift Sequencing (NIPSS)

J. Zhang, S. Yan, W. Guo, Y. Wang, Y. Wang, P. Zhang, H.-Y. Chen, S. Huang

This paper introduces NIPSS, a nanopore sequencing method for direct miRNA sequencing, demonstrating single-molecule resolution and potential applications in cancer diagnostics and therapeutics.

bioRxiv · Aug 27, 2019 · PreprintBiophysics

First report of Telenomus remus parasitizing Spodoptera frugiperda and its natural parasitism in South China

Y.-L. Liao, B. Yang, M.-F. Xu, W. Lin, D.-S. Wang, K.-W. Chen, H.-Y. Chen

The paper reports the first detection of Telenomus remus parasitizing Spodoptera frugiperda eggs in South China and estimates natural parasitism rates.

bioRxiv · Jul 11, 2019Zoology