HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cells
H. Wu, X. Zhao, S. M. Hochrein, M. Eckstein, G. F. Gubert, K. Knoepper, A. M. Mansilla, A. Oener, R. Doucet-Ladeveze, W. Schmitz, B. Ghesquiere, S. Theurich, J. Dudek, G. Gasteiger, A. Zernecke-Madsen, , M. Vaeth
This study identifies HIF-1α-mediated metabolic reprogramming as a mechanism controlling the transition of precursor T cells to terminally exhausted T cells in chronic infections and cancer.
bioRxiv · Aug 31, 2023 · PreprintImmunology