Author

W. Schmitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

A. Schulze· 3 shared K. Rajeeve· 2 shared L. Schlicker· 2 shared N. Vollmuth· 2 shared S. Janaki-Raman· 2 shared T. Rudel· 2 shared A. Baluapuri· 1 shared A. E. Mayer· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

A. Schulze

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cells

H. Wu, X. Zhao, S. M. Hochrein, M. Eckstein, G. F. Gubert, K. Knoepper, A. M. Mansilla, A. Oener, R. Doucet-Ladeveze, W. Schmitz, B. Ghesquiere, S. Theurich, J. Dudek, G. Gasteiger, A. Zernecke-Madsen, , M. Vaeth

This study identifies HIF-1α-mediated metabolic reprogramming as a mechanism controlling the transition of precursor T cells to terminally exhausted T cells in chronic infections and cancer.

bioRxiv · Aug 31, 2023 · PreprintImmunology

Acinar-to-ductal metaplasia in the pancreas requires a glycolytic switch and functional mitochondria

T. Neuss, N. Wirges, M.-C. Chen, S. Usluer, R. Oellinger, S. Lier, M. Dudek, T. Madl, M. Jastroch, K. Steiger, W. Schmitz, H. Einwaechter, R. M. Schmid

This study identifies a glycolytic switch and functional mitochondria as essential for acinar-to-ductal metaplasia, a key step in pancreatic carcinogenesis.

bioRxiv · Jun 27, 2022 · PreprintCancer Biology

Selenocysteine metabolism is a targetable vulnerability in MYCN-amplified cancers

H. Alborzy, Z. Chen, U. Yildiz, F. Porto- Freitas, F. C. E. Vogel, J. Varga, J. Batani, C. Bartenhagen, W. Schmitz, G. Buechel, B. Michalke, J. Zheng, S. Meierjohann, E. Girardi, E. Espinet, , J. P. Friedmann Angeli

This study identifies LRP8 as a targetable vulnerability in MYCN-amplified neuroblastoma by showing its role in selenocysteine import and resistance to ferroptosis.

bioRxiv · May 17, 2022 · PreprintCancer Biology

c-Myc plays a key role in IFN-γ induced persistence of Chlamydia trachomatis

N. Vollmuth, S. Janaki-Raman, L. Schlicker, N. Kurmasheva, W. Schmitz, A. Schulze, T. Rudel, K. Rajeeve

This study shows that IFN-γ induces Chlamydia persistence by depleting c-Myc, which is regulated by the PI3K-GSK3β axis and L-tryptophan levels, challenging the IDO depletion hypothesis.

bioRxiv · Mar 9, 2021Microbiology

A phosphoproteomic approach reveals that PKD3 controls phenylalanine and tyrosine metabolism

A. E. Mayer, A. Loza Valdes, W. Schmitz, J. Trujillo Viera, M. Leitges, A. Schlosser, G. Sumara

This study identifies PKD3 as a regulator of phenylalanine to tyrosine conversion in the liver through phosphoproteomic analysis.

bioRxiv · Jul 20, 2020Biochemistry

A central role of glutamine in Chlamydia infection

K. Rajeeve, N. Vollmuth, S. Janaki-Raman, T. Wulff, M. Schmalhofer, W. Schmitz, A. Baluapuri, C. Huber, J. Fink, F. R. Dejure, E. Wolf, W. Eisenreich, A. Schulze, J. Seibel, T. Rudel

This study identifies glutamine as essential for Chlamydia's EB-RB transition and shows that host glutamine metabolism is reprogrammed to support bacterial growth.

bioRxiv · Aug 27, 2019 · PreprintMicrobiology