M. F. Pedersen

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells

This study uses CRISPR/Cas9 to knockout GRK2 and GRK3 in HEK293 cells to assess their roles in μ-opioid receptor internalization and β-arrestin2 recruitment, finding GRK2 more critical than GRK3.

Structural insights into ligand efficacy and activation of the glucagon receptor

The paper presents the cryo-EM structure of the glucagon receptor bound to a ligand and G-protein, revealing structural insights into ligand efficacy and activation mechanism.