Cholangiocytic differentiation drives cell proliferation in hepatoblastoma through Wnt-dependent FGF19 signaling
P. V. Wu, M. Fish, F. K. Hazard, C. Zhu, S. Vennam, H. E. Walton, M. Morri, N. Neff, R. B. West, R. Nusse
The paper identifies FGF19 as a paracrine signal driving tumor growth in hepatoblastoma through Wnt-dependent mechanisms and biliary lineage activation.
bioRxiv · Jun 8, 2023Cancer Biology