P. Wu

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

A smartphone-based genetically recombinant whole-cell biosensor for highly sensitive monitoring of polychlorinated biphenyls (PCBs)

This paper develops a genetically engineered whole-cell biosensor using E. coli to detect multiple PCB congeners with high sensitivity, and integrates it with a smartphone for real-time monitoring.

pH-Sensitive Nanodroplets for Controlled Delivery of Berberine Chloride

This paper develops pH-sensitive nanodroplets for controlled berberine chloride delivery, showing high encapsulation efficiency and ultrasound-enhanced release.

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

UBA1-CDK16: A Sex-Specific Chimeric RNA and Its Role in Immune Sexual Dimorphism

The paper identifies a female-specific chimeric RNA, UBA1-CDK16, and shows its role in myeloid differentiation and immune sexual dimorphism.

A ZBP1 isoform blocks ZBP1-mediated cell death

This paper identifies a ZBP1 isoform (ZBP1-S) that suppresses ZBP1-mediated cell death by competing for Z-NA binding, revealing alternative splicing as a regulatory mechanism for inflammation.

Power-law growth models explain incidences and sizes of pancreatic cancer precursor lesions and confirm spatial genomic findings

The paper uses AI-based 3D tissue mapping to show PanIN lesion sizes follow a power-law distribution and identifies growth mechanisms driving pancreatic cancer precursor lesions.

An axonemal intron splicing program sustains Plasmodium male development

This study identifies RBPm1 as a splicing activator essential for axoneme assembly in Plasmodium male gametogenesis, revealing an intron splicing program critical for male development.

The canonical single-stranded DNA binding protein SSB is not an essential replication protein but an RNA chaperon in the hyperthermophilic archaeon Saccharolobus islandicus REY15A

This study shows that the canonical SSB in Saccharolobus islandicus REY15A is not essential for DNA replication but functions as an RNA chaperone, with conserved activities in related archaea.

Ser14-RPN6 Phosphorylation Mediates the Activation of 26S Proteasomes by cAMP and Protects against Cardiac Proteotoxic Stress in Mice

Transient EZH2 suppression by Tazemetostat during in vitro expansion maintains T cell stemness and improves adoptive T cell therapy

The paper shows that transient EZH2 inhibition with Tazemetostat during T cell expansion maintains stemness and improves adoptive T cell therapy outcomes in a murine model.

Nanobodies for the treatment of SARS-CoV-2 in animals: a meta-analysis

This meta-analysis evaluates the protective effects of VHHs against SARS-CoV-2 in animals, finding significant protection with low heterogeneity.

Chemoenzymatic Measurement of Cell-surface Glycan in Single-cell Multiomics: LacNAc as an Example

The paper introduces a chemoenzymatic method to detect cell-surface glycan in single-cell multiomics, showing increased LacNAc in activated CD8+ T cells and its correlation with glycolytic activity.

The archaeal KEOPS complex possesses a functional Gon7 homolog and has an essential function independent of cellular t6A modification level

This study identifies the archaeal KEOPS complex subunits and shows its essential function independent of t6A modification.

FOXP2 confers oncogenic effects in prostate cancer through activating MET signalling

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

Enhancing the anti-tumor efficacy of Bispecific T cell engagers via cell surface glycocalyx editing

This study develops BiTE-sialidase fusion proteins that enhance anti-tumor efficacy by desialylating tumor cells, improving T-cell activation and cytolysis in vitro and in vivo.

Flavivirus prM interacts with MDA5 and MAVS to inhibit RLR antiviral signaling

This study identifies how flavivirus prM proteins interact with MDA5 and MAVS to inhibit RLR antiviral signaling, revealing species-dependent immune evasion mechanisms.

High-titer production of aromatic amines in metabolically engineered Escherichia coli

This paper reports the high-titer production of aromatic amines in engineered E. coli by optimizing carbon source and deleting fermentation byproduct genes.

Single-nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

A high-density lineage tree reveals dynamics of expression differences accumulation in nondifferentiating clonal expansion

The paper develops a method to track transcriptome differences in clonal expansion and shows constrained expression noise dynamics during cell divisions.

Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver.

This study shows intermittent fasting induces rapid hepatocyte proliferation in mice to maintain liver-to-body-mass ratio, challenging the view that liver tissue is quiescent unless injured.

Hepatocyte Cell Cycle Progression Depends on a Transcriptional Repressor Cascade Downstream of Wnt Signaling

The paper identifies a transcriptional repressor cascade downstream of Wnt signaling that controls hepatocyte cell cycle progression by repressing E2F7 and E2F8.

Early megakaryocyte lineage-committed progenitors in adult mouse bone marrow

This study identifies early megakaryocyte lineage-committed progenitors in adult mouse bone marrow and proposes a differentiation model involving intermediate progenitors.

WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

Characterisation of a novel ACE2-based therapeutic with enhanced rather than reduced activity against SARS-CoV2 variants

The paper characterizes a novel ACE2-based therapeutic that effectively neutralizes SARS-CoV-2 variants and demonstrates antibody-like properties and manufacturability.

A CTLA-4 nanobody improves the immunity of mice against challenges with Staphylococcus aureus and Streptococcus agalactiae

This study shows that a CTLA-4 nanobody enhances immune responses in mice challenged with Staphylococcus aureus and Streptococcus agalactiae.

Discovery of a molecular glue that enhances UPRmt to restore proteostasis via TRKA-GRB2-EVI1-CRLS1 axis

This study identifies ginsenoside Rg3 as a molecular glue that enhances mitochondrial UPR via the TRKA-GRB2-EVI1-CRLS1 axis to restore proteostasis in Parkinson's disease.

SARS-CoV-2 nucleocapsid protein dually regulates innate immune responses

This study shows that SARS-CoV-2 N protein modulates innate immunity by both suppressing and promoting IFN-I and inflammatory responses depending on its dosage.

L-WNK1 is required for BK channel activation in intercalated cells

This study shows that L-WNK1 in intercalated cells enhances BK channel activity in response to a high K+ diet, which is critical for urinary K+ secretion.

Controlling Cellular Arrangements via Stretched Bioprinting

This paper introduces a bioprinting method that controls cellular orientation through stretching, enabling aligned myofiber formation and effective tissue repair in vivo.