Author

M. Garcia-Borras

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Approach:experimental assay· 3 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

K. N. Houk· 2 shared A. Bar-Even· 1 shared A. N. Lowell· 1 shared C. Calvo-Tusell· 1 shared C. G. Acevedo-Rocha· 1 shared C. S. Jamieson· 1 shared D. H. Sherman· 1 shared F. Feixas· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

K. N. Houk

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Author profile →

5 papers

Recent·Most cited

Structural and mechanistic views of enzymatic, heme-dependent nitrogen-nitrogen bond formation

M. A. Higgins, X. Shi, J. Soler, J. B. Harland, T. Parkkila, N. Lehnert, M. Garcia-Borras, Y.-L. Du, K. S. Ryan

This study investigates the structural and mechanistic basis of N-N bond formation by the heme-dependent enzyme PipS, revealing divergent pathways and a shared nitrenoid intermediate.

bioRxiv · Dec 15, 2023 · PreprintBiochemistry

Changes in protonation states of in-pathway residues can alter ligand binding pathways obtained from spontaneous binding molecular dynamics simulations

H. Girame, M. Garcia-Borras, F. Feixas

This study shows that protonation states of distal residues affect ligand binding pathways in MD simulations, using trypsin-benzamidine interactions as a case study.

bioRxiv · Apr 30, 2022 · PreprintBiophysics

In vivo selection for formate dehydrogenases with high efficiency and specificity towards NADP+

L. Calzadiaz Ramirez, C. Calvo-Tusell, G. M. M. Stoffel, S. Lindner, S. Osuna, T. J. Erb, M. Garcia-Borras, A. Bar-Even, C. G. Acevedo-Rocha

This study uses in vivo selection to engineer formate dehydrogenases with high efficiency and specificity for NADP+ regeneration.

bioRxiv · Apr 2, 2020 · PreprintBiochemistry

Structural Basis for Stereoselective Dehydration and Hydrogen-Bonding Catalysis by the SAM-Dependent Pericyclase LepI

Y. Cai, Y. Hai, M. Ohashi, C. S. Jamieson, M. Garcia-Borras, K. N. Houk, J. Zhou, Y. Tang

This paper determines the structural basis for the stereoselective dehydration and hydrogen-bonding catalysis by LepI, revealing how it functions as a multifunctional pericyclase.

bioRxiv · Dec 10, 2018Biochemistry

Structural basis of the Cope rearrangement and C-C bond-forming cascade in hapalindole/fischerindole biogenesis

S. A. Newmister, S. Li, M. Garcia-Borras, J. N. Sanders, S. Yang, A. N. Lowell, F. Yu, J. L. Smith, R. M. Williams, K. N. Houk, D. H. Sherman

This paper reports the structure of HpiC1, a Stig cyclase involved in hapalindole/fischerindole biosynthesis, revealing its dimeric assembly and key residues for catalytic steps.

bioRxiv · Aug 8, 2017Biochemistry