R. M. Williams

This paper develops a noninvasive optical nanosensor-hydrogel hybrid that detects doxorubicin in live mice, showing stability and functionality over several weeks.

The paper provides practical guidelines for mounting and imaging cleared tissues using lightsheet microscopy in standardized optical cuvettes, improving reproducibility and cost-effectiveness.

This study develops edaravone-loaded mesoscale nanoparticles for treating cisplatin-induced acute kidney injury, showing improved renal function and reduced oxidative stress in mice.

This study identifies imidazolopiperazines as targeting the Plasmodium falciparum secretory pathway by inhibiting protein trafficking and ER expansion.

The paper presents the structure of nucleotide-bound Tel1ATM, revealing molecular mechanisms of inhibition and explaining disease-related mutations.

This paper reports the structure of HpiC1, a Stig cyclase involved in hapalindole/fischerindole biosynthesis, revealing its dimeric assembly and key residues for catalytic steps.