Author

L. Janssen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:behavioral assay· 1 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. Neefjes· 2 shared A. A. de Waard· 1 shared A. E. X. Brown· 1 shared A. Margiotta· 1 shared A. Mulder· 1 shared A. Xagara· 1 shared B. Cabukusta· 1 shared B. Martinez· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

J. Neefjes

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rebalancing the motor circuit restores movement in a Caenorhabditis elegans model for TDP-43-toxicity

M. Koopman, L. Gungordu, L. Janssen, R. I. Seinstra, J. E. X. Richmond, N. Okerlund, R. Wardenaar, P. Islam, A. E. X. Brown, E. M. Jorgensen, E. A. A. Nollen

This study identifies that rebalancing excitatory and inhibitory inputs in C. elegans restores movement in a TDP-43 toxicity model by synergizing neurotransmitter system enhancements.

bioRxiv · Oct 24, 2023 · PreprintCell Biology

Cold exposure induces dynamic changes in circulating triacylglycerol species, which is dependent on intracellular lipolysis: a randomized cross-over trial

M. Straat, L. Jurado Fasoli, Z. Ying, K. J. Nahon, L. Janssen, M. Boon, G. Grabner, S. Kooijman, R. Zimmermann, M. Giera, P. C. Rensen, B. Martinez

This study shows cold exposure increases circulating free fatty acids and transiently lowers total triacylglycerols in humans, with dynamic changes in TAG species dependent on saturation and chain length, and this effect is mediated by intracellular lipolysis.

bioRxiv · Sep 9, 2022Physiology

The SPPL3-defined glycosphingolipid repertoire regulates immune responses by improving HLA class I access

M. L. M. Jongsma, M. Raaben, A. A. de Waard, T. Zhang, B. Cabukusta, R. Platzer, V. A. Blomen, A. Xagara, T. Verkerk, S. Bliss, L. Janssen, E. Stickel, S. Holst, R. Plomp, A. Mulder, , R. M. Spaapen

The paper identifies a glycosphingolipid (GSL) signature that inhibits HLA-I antigen presentation and shows its reversal by clinically approved drugs.

bioRxiv · Sep 26, 2020Immunology

Invariant chain regulates endosomal fusion and maturation through the SNARE Vti1b

D. Frei, A. Margiotta, M. Borg Distefano, M. Moulefera, L. Janssen, J. Thibodeau, J. Neefjes, O. Bakke

This study identifies Vti1b as a SNARE protein that interacts with invariant chain (Ii) to regulate endosomal fusion and maturation, delaying endosomal maturation for efficient antigen processing.

bioRxiv · Sep 18, 2019 · PreprintCell Biology