DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity
D. J. Wilcock, A. P. Badrock, R. Owen, M. Guerin, A. D. Southam, H. Johnston, S. Ogden, P. Fullwood, J. Watson, H. Ferguson, J. Haworth, D. A. Richardson, G. R. Lloyd, A. Jankevics, W. B. Dunn, , A. F. L. Hurlstone
This study identifies DGAT1 as an oncoprotein that enables cancer cells to accumulate fatty acids while avoiding lipotoxicity, promoting melanoma formation.
bioRxiv · Jun 23, 2020 · PreprintCancer Biology