Author

R. Coppee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 2 Organism:plant (other)· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Clain· 3 shared A.-C. Langlois· 2 shared C. Marinach· 2 shared O. Silvie· 2 shared A. Ashish· 1 shared A. Rahman· 1 shared A. Sabbagh· 1 shared D. Jeffares· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersBiochemistry

J. Clain

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Author profile →

5 papers

Recent·Most cited

Artemisinin-resistant Plasmodium falciparum Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activation

A. Rahman, S. Tamseel, R. Coppee, S. Dutta, N. Khan, M. Faaiz, H. Rastogi, J. R. Nath, P. Chowdhury, A. Ashish, J. Clain, S. Bhattacharjee

This study shows that PfKelch13 mutants have reduced heme-binding affinity, leading to decreased artemisinin activation and contributing to artemisinin resistance.

bioRxiv · Jan 23, 2024 · PreprintBiochemistry

Genetic profiling of Plasmodium ovale wallikeri relapses with microsatellite markers and whole-genome sequencing

V. Joste, E. Colard-Itte, E. Guillochon, F. Ariey, R. Coppee, J. Clain, S. Houze, French National Reference Center for Imported Malaria Study Group

The paper investigates relapse patterns in Plasmodium ovale wallikeri infections using microsatellite markers and whole-genome sequencing, finding that most relapses are genetically related to primary infections.

bioRxiv · Feb 1, 2023 · PreprintMicrobiology

Plasmodium sporozoites require the protein B9 to invade hepatocytes

P. Fernandes, M. Loubens, C. Marinach, R. Coppee, M. Grand, T.-P. Andre, S. Hamada, A.-C. Langlois, S. Briquet, P. Bun, O. Silvie

This study identifies B9 as a critical protein for Plasmodium sporozoite invasion of hepatocytes, revealing structural and functional similarities to merozoite invasion complexes.

bioRxiv · Oct 25, 2021Microbiology

Molecular determinants of SR-B1-dependent Plasmodium sporozoite entry into hepatocytic cells.

A.-C. Langlois, G. Manzoni, L. Vincensini, R. Coppee, C. Marinach, M. Guerin, T. Huby, V. Carriere, F.-L. Cosset, M. Dreux, E. Rubinstein, O. Silvie

This study identifies structural determinants of SR-B1 required for Plasmodium sporozoite entry into hepatocytes using chimeric mouse/human SR-B1 constructs and structure-guided analysis.

bioRxiv · Mar 16, 2020Microbiology

Structural evolutionary analysis predicts functional sites in the artemisinin resistance malaria protein K13

R. Coppee, D. Jeffares, A. Sabbagh, J. Clain

The paper identifies conserved regions in the K13 protein of Plasmodium falciparum as potential functional sites using evolutionary and structural analysis.

bioRxiv · Jun 21, 2018 · PreprintEvolutionary Biology