Author

K. Dower

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Wang· 3 shared F. J. Schlerman· 2 shared R. Martinez· 2 shared S. Asano· 2 shared S. M. Christensen· 2 shared S. Zhao· 2 shared T. A. Wynn· 2 shared T. Fabre· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

J. Wang

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Stricturing Crohn's disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions

P. K. Mukherjee, Q. T. Nguyen, J. Li, S. Zhao, S. M. Christensen, G. A. West, J. Chandra, I. O. Gordon, S. Lin, J. Wang, R. Mao, D. Czarnecki, C. Rayan, P. Kotak, T. Plesec, , F. Rieder

This study uses single-cell RNA sequencing to analyze fibroblast heterogeneity and interactions in Crohn's disease strictures, identifying CDH11 as a potential therapeutic target.

bioRxiv · Apr 3, 2023Immunology

Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation in Human and Murine Liver and Lung Fibrosis

T. Fabre, A. M. S. Barron, S. M. Christensen, S. Asano, M. H. Wadsworth, X. Chen, J. Wang, J. McMahon, F. J. Schlerman, A. White, K. M. Hart, K. Kravarik, A. J. Fisher, L. A. Borthwick, N. C. Henderson, , K. Dower

The paper identifies a fibrogenic macrophage subset linked to liver and lung fibrosis across species and shows that targeting specific cytokines reduces fibrosis in models.

bioRxiv · Jul 1, 2022 · PreprintImmunology

Pharmacologic inhibition of Protein Kinase C α and Protein Kinase C β halts renal function decline indirectly, by blunting hyperphagia, and directly reduces adiposity in the ZSF1 rat model of type 2 diabetes

J. Wang, A. Casimiro-Garcia, B. G. Johnson, J. Duffen, M. Cain, L. Savary, S. Wang, P. Nambiar, M. Lech, S. Zhao, L. Xi, Y. Zhan, J. Olson, J. A. Stejskal, H. Lin, , K. Dower

The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.

bioRxiv · Dec 2, 2020 · PreprintPharmacology & Toxicology