Expression and functional evaluation of recombinant human ABO blood group antigen cleaving glycoside hydrolases α-N-acetylgalactosaminidase, α-galactosidase, and endo-β-galactosidase produced in Escherichia coli
W. H. Toh, Y. Kuo, S. K. Hsu, B. Chen, A. J. Lee, E. Liaw, J. Lee, A. Cheng, L. Hwa, K. Hu, S. Chien, C. Wong, K. Chang, M. Hang, S. Hong, , J. Hsu
This study evaluates recombinant glycoside hydrolases for converting A, B, and AB blood types to O by cleaving surface antigens, showing partial success in porcine red blood cells.
bioRxiv · May 4, 2022 · PreprintBiochemistry