S. Hong

cMPL-Based Purification and Depletion of Human Hematopoietic Stem Cells: Implications for Pre-Transplant Conditioning

This study explores using cMPL as a target to selectively deplete human hematopoietic stem cells, showing potential for safer pre-transplant conditioning.

Glyoxalase 1: emerging biomarker and therapeutic target in cervical cancer progression

This study identifies Glyoxalase-1 (GLO1) as significantly upregulated in cervical cancer tissues and shows its role in cancer metabolism, suggesting it as a potential biomarker and therapeutic target.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling

This study shows that IPMK regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling, impacting immune responses and autoimmune disease models.

Impact of CRISPR/HDR-editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques

This study compares CRISPR/HDR and lentiviral transduction effects on HSPC engraftment and clonal dynamics in rhesus macaques, finding HDR-edited cells decline rapidly while lentiviral cells persist longer.

Mapping protein-exopolysaccharide binding interaction in Staphylococcus epidermidis biofilms by live cell proximity labeling

This study maps PNAG-binding proteins in S. epidermidis biofilms using proximity labeling and proteomics, identifying EbpS and its LysM domain as key interactors.

Actin Y53 Phosphorylation Regulates Somatic F-actin Radial Translocation to Promote Neuronal Polarization

This study identifies actin Y53 phosphorylation as a regulator of somatic F-actin translocation, which influences neuronal polarization during axon formation.

FcRγ- NK cell induction by specific CMV and expansion by subclinical viral infections in rhesus macaques

This study identifies RhCMV-specific induction of FcRγ-deficient NK cells in rhesus macaques, with co-infections enhancing their frequency.

Expression and functional evaluation of recombinant human ABO blood group antigen cleaving glycoside hydrolases α-N-acetylgalactosaminidase, α-galactosidase, and endo-β-galactosidase produced in Escherichia coli

This study evaluates recombinant glycoside hydrolases for converting A, B, and AB blood types to O by cleaving surface antigens, showing partial success in porcine red blood cells.

Massively Parallel Selection of NanoCluster Beacons

The paper develops a high-throughput method to screen and design multicolor NanoCluster Beacons using NGS chips and machine learning.

LBH is a cancer stem cell- and metastasis-driving oncogene essential for WNT stem cell function in breast cancer

This study identifies LBH as a key oncogene driving cancer stem cell function and metastasis in breast cancer through WNT pathway activation.

A Pan-respiratory Antiviral Chemotype Targeting a Host Multiprotein Complex

The paper identifies a novel antiviral chemotype effective against multiple respiratory viruses by targeting a host multi-protein complex involved in viral lifecycle and innate immunity.

Topoisomerase 2b induces DNA breaks to regulate human papillomavirus replication

This study shows that TOP2β induces DNA breaks to regulate HPV replication by interacting with CTCF/SMC1 at viral late regions, leading to DNA damage and impaired repair.

Deep learning enables rapid and robust analysis of fluorescence lifetime imaging in photon-starved conditions

This paper introduces flimGANE, a deep learning method that rapidly and accurately generates FLIM images in low-photon conditions, outperforming traditional methods in speed and analysis accuracy.

Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity

This study shows Hsp90 and Sti1 modulate TDP-43 misfolding, inclusion formation, and toxicity in neuronal cells.

Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon-anticodon pairing

The paper reports ribosome structures with tRNAPro bound to codons, showing how m1G37 modification prevents frameshifting by stabilizing tRNA interactions.

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

Modulation of Siglec-7 Signaling via in situ Created High-affinity cis-Ligands

The paper shows that modulating Siglec-7 signaling via high-affinity cis-ligands on NK cells can suppress or enhance NK cytotoxicity depending on ligand concentration.

Accommodating individual travel history, global mobility, and unsampled diversity in phylogeography: a SARS-CoV-2 case study.

This paper integrates travel history data into Bayesian phylogeographic analysis of SARS-CoV-2 to improve virus spread reconstructions and address sampling bias.

Glycoengineering of NK cells with glycan ligands of CD22 and selectins for B-cell lymphoma therapy

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.

Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through Growth Differentiation Factor 3

This study shows that preventing PPARγ S273 phosphorylation reduces insulin resistance without weight gain or side effects, identifying Gdf3 as a key mediator.

hFUT1-based live cell assay to profile α1-2-fucosides enhanced influenza A virus infection

This study develops a live cell assay using hFUT1 to profile α1-2-fucosides' role in enhancing influenza A virus infection.

In situ Fucosylation for Modulating Wnt Signaling in Live Cells

This study shows that fucosylation of N-glycans modulates Wnt signaling by affecting LRP6 endocytosis, revealing a new glycosylation-dependent regulatory mechanism.

Direct Visualization of Live Zebrafish Glycan via Single-step Metabolic Labeling with Fluorophore-tagged Nucleotide Sugars

The paper develops a single-step fluorescent glycan labeling method to image sialylation and fucosylation in live zebrafish embryos, revealing their roles in hematopoiesis.

Altitudinal range-size distribution of breeding birds and environmental factors for the determination of species richness: An empirical test of altitudinal Rapoports rule and rescue effect on a local scale

This study tests altitudinal Rapoports rule and rescue effect by analyzing species range-size distribution and environmental factors, finding support for Rapoports rule and climatic hypothesis but not ambient energy hypothesis.

Single-Virion Sequencing Of Lamivudine Treated HBV Populations Reveal Population Evolution Dynamics And Demographic History

This study uses single-virion sequencing to analyze HBV population dynamics in treated patients, revealing selective sweeps and demographic history.