Author

M. Hecker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 3 Physiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:metabolomics· 2 Approach:benchmark study· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:ecology & biodiversity· 1 Organism:mouse· 1

Frequent Co-Authors

M. Brinkmann· 3 shared N. Hogan· 3 shared C. Roberts· 2 shared E. Kohlman· 2 shared N. Jain· 2 shared S. Wiseman· 2 shared A. Abukiwan· 1 shared A. J. Alcaraz· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

M. Brinkmann

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Xenometabolome of Early-Life Stage Salmonids Exposed to 6PPD-Quinone

P. J. Ankley, F. C. da Silva, B. Hunnie, C. Roberts, A. N. M. Eriksson, E. Kohlman, J. Corker, J. Westcott, B. Germain, M. J. Martin, J. Dubiel, K. Anderson-Bain, R. M. Urrutia, N. Hogan, J. P. Giesy, , M. Brinkmann

This study examines differences in 6PPD-Q biotransformation and metabolome responses among early-life stage salmonids, finding that brown trout detoxify it more effectively than sensitive species.

bioRxiv · Jun 12, 2024Pharmacology & Toxicology

Acute and sub-chronic toxicity of 6PPD-quinone to early-life stage lake trout (Salvelinus namaycush)

C. Roberts, J. Lin, E. Kohlman, N. Jain, M. Amekor, A. J. Alcaraz, N. Hogan, M. Hecker, M. Brinkmann

This study assesses the acute and sub-chronic toxicity of 6PPD-quinone to early-life stage lake trout, finding significant mortality and deformities at environmentally relevant concentrations.

bioRxiv · Mar 26, 2024 · PreprintPhysiology

NFAT5-dependent transcriptional stress control of endothelial cells prevents maladaptive remodeling of pulmonary arterioles in the hypoxic lung

H. Laban, S. Siegmund, K. Schlereth, L. Brandenburg, F. A. Trogisch, A. Weigert, C. De La Torre, A. Abukiwan, C. Mogler, M. Hecker, W. M. Kuebler, T. Korff

This study shows that NFAT5 in endothelial cells limits hypoxia-induced maladaptive remodeling of pulmonary arterioles by restricting HIF1-mediated Pdgfb expression.

bioRxiv · Oct 18, 2023Physiology

Toxicokinetic Characterization of the Inter-Species Differences in 6PPD-Quinone Toxicity Across Seven Fish Species: Metabolite Identification and Semi-Quantification

D. J. Montgomery, X. Ji, J. Cantin, D. Philibert, G. Foster, S. Selinger, N. Jain, J. Miller, J. McIntyre, B. de Jourdan, S. Wiseman, M. Hecker, M. Brinkmann

This study identifies and semi-quantifies 6PPD-Quinone metabolites in fish species to explore inter-species differences in toxicity and detoxification.

bioRxiv · Aug 18, 2023 · PreprintPharmacology & Toxicology

Resource requirements for ecotoxicity testing: A comparison of traditional and new approach methods

K. Mittal, D. Crump, J. Head, M. Hecker, G. Hickey, S. Maguire, N. Hogan, J. Xia, N. Basu

This study compares resource requirements of traditional and new approach methods in ecotoxicity testing, finding NAMs are cheaper, use fewer animals, and are faster.

bioRxiv · Feb 24, 2022 · PreprintPharmacology & Toxicology