M. Howard

CYpHER: Catalytic extracellular targeted protein degradation with high potency and durable effect

CYpHER is a targeted protein degradation technology that uses pH-dependent release and the transferrin receptor to deliver drugs to endolysosomes, demonstrating potency and durability in vitro and in vivo.

Female cichlids attack and avoid-but will still mate with-androgen receptor mutant males that lack male-typical body coloration

The paper investigates female cichlid mating behaviors by testing AR mutant males lacking coloration, finding aggression but mating occurs regardless of coloration.

Amyloidogenic Propensity of Self-Assembling Peptides and their Adjuvant Potential for use as DNA Vaccines

This study characterizes the amyloidogenic properties of a self-assembling peptide and demonstrates its safety and adjuvant potential as a DNA vaccine platform.

Reassessment of the basis of cell size control based on analysis of cell-to-cell variability

The paper reassesses cell size control mechanisms by analyzing cell-to-cell variability in fission yeast, showing that apparent deviations from theoretical models arise from geometric measurement errors and variability.

A gated relaxation oscillator controls morphogenetic movements in bacteria

The paper identifies a gated relaxation oscillator mechanism in Myxococcus xanthus that controls polarity reversals through FrzX and RomR, enabling tunable motility responses.