T. Mignot

Fatty Acid Metabolism and The Oxidative Stress Response Support Bacterial Predation

This study identifies genetic and metabolic adaptations in Myxococcus xanthus that enhance bacterial predation by activating fatty acid metabolism and antioxidant responses.

Integrin-like adhesin CglD confers traction and stabilizes bacterial focal adhesions involved in myxobacterial gliding motility

The paper identifies CglD as a β-integrin-like adhesin in Myxococcus xanthus that stabilizes bacterial focal adhesions and enables gliding motility through mechanosensory and mechanotransductory functions.

Multi-scale dynamic imaging reveals that cooperative motility behaviors promote efficient predation in bacteria

The paper uses multiscale imaging to show that cooperative motility behaviors in Myxococcus xanthus enhance predation efficiency by combining A- and S-motile cells.

Dynamic proton-dependent motors power Type IX secretion and gliding adhesin movement in Flavobacterium

A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria

This study identifies a new type IV filament-like machinery, Kil, involved in contact-dependent prey killing by Myxococcus xanthus, showing its role in motility arrest and prey cell plasmolysis.

MiSiC, a general deep learning-based method for the high-throughput cell segmentation of complex bacterial communities

MiSiC is a deep learning method for segmenting bacterial cells in complex communities, enabling analysis of interspecies interactions with minimal parameter adjustment.

CglB adhesins secreted at bacterial focal adhesions mediate gliding motility

The paper identifies CglB as a substratum-coupling protein secreted by the gliding complex in Myxococcus xanthus, revealing a mechanism for force transduction and a novel secretion process.

Modulation of bacterial multicellularity via spatiotemporal polysaccharide secretion

The paper shows that Myxococcus xanthus uses temporally and spatially controlled polysaccharide secretion to coordinate multicellular behaviors like swarm migration and biofilm formation.

Establishing Rod-Shape from Spherical, Peptidoglycan-Deficient Bacterial Spores

This study investigates how peptidoglycan-deficient spherical spores of Myxococcus xanthus germinate into rod-shaped cells by elucidating the role of MglB, MglA, MreB, and molecular motors in de novo PG synthesis and shape establishment.

A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays

The paper identifies FrzB, a divergent CheW in M. xanthus, which lacks the CheA-interacting region and functions upstream of FrzCD to enable distributed chemosensory arrays on the nucleoid, conferring plasticity to chemosensory systems.

Chitosan films for microfluidic studies of single bacteria and perspectives for antibiotics susceptibility testing

This paper develops chitosan films for single-cell microfluidics to study bacterial growth and antibiotic susceptibility, achieving faster and more accurate results than current methods.

MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus

This study identifies MglA's two GTP-bound states and their roles in controlling movement reversals in Myxococcus xanthus.

The nucleoid as a scaffold for the assembly of bacterial signaling complexes

The paper shows that FrzCD chemoreceptors bind the bacterial nucleoid non-sequence-specifically, forming distributed clusters that enable cooperative signaling.

A gated relaxation oscillator controls morphogenetic movements in bacteria

The paper identifies a gated relaxation oscillator mechanism in Myxococcus xanthus that controls polarity reversals through FrzX and RomR, enabling tunable motility responses.