Author

U. Nattermann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1

Frequent Co-Authors

A. K. Bera· 2 shared A. Kang· 2 shared D. Baker· 2 shared W. Sheffler· 2 shared Y. Hsia· 2 shared A. Antanasijevic· 1 shared A. Courbet· 1 shared A. J. Borst· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

A. K. Bera

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains

J. Y. Wang, A. Khmelinskaia, W. Sheffler, M. C. Miranda, A. Antanasijevic, A. J. Borst, S. V. Torres, C. Shu, Y. Hsia, U. Nattermann, D. Ellis, C. Walkey, M. Ahlrichs, S. Chan, A. Kang, , N. P. King

This study identifies cryptic transmembrane domains in designed protein nanoparticles that hinder secretion and introduces a computational tool, Degreaser, to remove them while maintaining stability, improving secretion efficiency.

bioRxiv · Aug 4, 2022Biochemistry

Hierarchical design of multi-scale protein complexes by combinatorial assembly of oligomeric helical bundle and repeat protein building blocks

Y. Hsia, R. Mout, W. Sheffler, N. I. Edman, I. Vulovic, Y.-J. Park, R. L. Redler, M. J. Bick, A. K. Bera, A. Courbet, A. Kang, T. Brunette, U. Nattermann, E. Tsai, A. Saleem, , D. Baker

This paper describes a hierarchical method to design multi-scale symmetric protein complexes using repeat proteins and helical bundles, resulting in large symmetric assemblies like an icosahedral nanocage.

bioRxiv · Jul 27, 2020Biochemistry

Gatekeeper helix activates Golgi SM protein Sly1 and directly mediates close-range vesicle tethering

M. Duan, R. L. Plemel, T. Takenaka, A. Lin, B. M. Delgado, U. Nattermann, D. P. Nickerson, J. Mima, E. A. Miller, A. J. Merz

The paper identifies a gatekeeper helix in Sly1 that binds membranes to relieve autoinhibition and mediate close-range vesicle tethering in the early secretory pathway.

bioRxiv · Jan 16, 2020 · PreprintCell Biology