Author

Y. Hsia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Bioengineering· 3

Signature Assays, Organisms & Methods

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Assay:protein structure· 6 Approach:deep learning· 5 Research Focus:protein design· 4 Research Focus:protein folding & dynamics· 4 Approach:statistical model· 4 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

D. Baker· 7 shared A. J. Borst· 3 shared A. K. Bera· 3 shared A. Kang· 3 shared W. Sheffler· 3 shared A. Courbet· 2 shared A. Khmelinskaia· 2 shared B. Sankaran· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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7 shared papersBiochemistry

D. Baker

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Design of four component T=4 tetrahedral, octahedral, and icosahedral protein nanocages through programmed symmetry breaking

S. Lee, R. D. Kibler, Y. Hsia, A. J. Borst, A. Philomin, M. A. Kennedy, B. L. Stoddard, D. Baker

The paper designs T=4 protein nanocages with tetrahedral, octahedral, and icosahedral symmetries using pseudo-symmetrization of trimeric building blocks, resulting in structures with distinct subunits and interfaces.

bioRxiv · Jun 16, 2023 · PreprintBiochemistry

Hierarchical design of pseudosymmetric protein nanoparticles

Q. Dowling, Y.-J. Park, N. Gerstenmaier, E. Yang, A. Wargacki, Y. Hsia, C. Fries, R. Ravichandran, C. Walkey, A. Burrell, D. Veesler, D. Baker, N. King

The paper designs large pseudosymmetric protein nanoparticles using a hierarchical computational method, achieving sizes up to 96 nm with 960 subunits.

bioRxiv · Jun 16, 2023 · PreprintBioengineering

Blueprinting expandable nanomaterials with standardized protein building blocks

T. F. Huddy, Y. Hsia, R. D. Kibler, J. Xu, N. Bethel, D. Nagarajan, R. Redler, P. J. Y. Leung, A. Courbet, E. C. Yang, A. K. Bera, N. Coudray, S. J. Calise, F. A. Davila-Hernandez, C. Weidle, , D. Baker

This paper introduces standardized protein building blocks and geometric design principles to create expandable protein nanomaterials, validated through X-ray crystallography and electron microscopy.

bioRxiv · Jun 9, 2023Biochemistry

De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity

R. Mout, R. C. Bretherton, J. Decarreau, S. Lee, N. I. Edman, M. Ahlrichs, Y. Hsia, D. D. Sahtoe, G. Ueda, N. Gregorio, A. Sharma, R. Schulman, C. A. DeForest, D. Baker

This paper designs modular protein hydrogels with tunable viscoelasticity by controlling molecular parameters and demonstrates their use both intra- and extracellularly.

bioRxiv · Jun 2, 2023Bioengineering

Fast and versatile sequence-independent protein docking for nanomaterials design using RPXDock

W. Sheffler, E. C. Yang, Q. Dowling, Y. Hsia, C. N. Fries, J. Stanislaw, M. Langowski, M. Brandys, A. Khmelinskaia, N. P. King, D. Baker

RPXDock enables fast, flexible protein docking for symmetric architectures, supporting diverse applications in nanomaterial design.

bioRxiv · Oct 25, 2022Bioengineering

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains

J. Y. Wang, A. Khmelinskaia, W. Sheffler, M. C. Miranda, A. Antanasijevic, A. J. Borst, S. V. Torres, C. Shu, Y. Hsia, U. Nattermann, D. Ellis, C. Walkey, M. Ahlrichs, S. Chan, A. Kang, , N. P. King

This study identifies cryptic transmembrane domains in designed protein nanoparticles that hinder secretion and introduces a computational tool, Degreaser, to remove them while maintaining stability, improving secretion efficiency.

bioRxiv · Aug 4, 2022Biochemistry

Hierarchical design of multi-scale protein complexes by combinatorial assembly of oligomeric helical bundle and repeat protein building blocks

Y. Hsia, R. Mout, W. Sheffler, N. I. Edman, I. Vulovic, Y.-J. Park, R. L. Redler, M. J. Bick, A. K. Bera, A. Courbet, A. Kang, T. Brunette, U. Nattermann, E. Tsai, A. Saleem, , D. Baker

This paper describes a hierarchical method to design multi-scale symmetric protein complexes using repeat proteins and helical bundles, resulting in large symmetric assemblies like an icosahedral nanocage.

bioRxiv · Jul 27, 2020Biochemistry